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EGFR (ErbB1) [T790M] Recombinant Human Protein, Invitrogen™ DFS Item

EGFR (ErbB1) [T790M] Recombinant Human Protein

$574.00 - $574.00

Specifications

Accession Number NP_005219.2; T790M
Assays EGFR T790M was pre-diluted in enzyme dilution buffer and assayed in 25mM HEPES (pH 7.5), 10mM MgCl2, 0.5mM EGTA, 0.5mM Na3VO4, 5mM β-glycerophosphate, 2.5mM DTT, 0.01% Triton™ X-100, 200μM ATP, 200μg/mL Abl1 peptide substrate (EAIYAAPFAKKK) and trace [32P]-γ-ATP for 10 minutes at 30°C
Common Name EGFR (ErbB1) [T790M] Recombinant Human Protein
Concentration 0.29mg/mL
Expression System Baculovirus
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Catalog Number Mfr. No. Quantity Price Quantity  
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Description

Description

The epidermal growth factor receptor is a receptor tyrosine kinases that signals in response to various growth factors. Overexpression has been linked to numerous types of cancer and EGFR is the target of both biological and small molecular therapeutics. The T790M mutant of EGFR has arisen in the clinics and displays resistance to Erlotinib (Tarceva) and Gefitinib (Iressa).
Specifications

Specifications

NP_005219.2; T790M
EGFR (ErbB1) [T790M] Recombinant Human Protein
Baculovirus
EGF receptor (ErbB)
EGFR (ErbB1) [T790M] Recombinant Human Protein
EGFR (ErbB1) [T790M] Recombinant Human Protein
For research use only. Not for use in diagnostic procedures
–80°C
Human
EGFR T790M was pre-diluted in enzyme dilution buffer and assayed in 25mM HEPES (pH 7.5), 10mM MgCl2, 0.5mM EGTA, 0.5mM Na3VO4, 5mM β-glycerophosphate, 2.5mM DTT, 0.01% Triton™ X-100, 200μM ATP, 200μg/mL Abl1 peptide substrate (EAIYAAPFAKKK) and trace [32P]-γ-ATP for 10 minutes at 30°C
0.29mg/mL
EGFR (ErbB1) T790M
90.5kDa
1 Each
70% by SDS-PAGE
43nmoles of phosphate transferred to Abl1 peptide substrate (EAIYAAPFAKKK) per minute per mg of total protein at 30°C. Activity determined at a final protein concentration of 6.67μg/mL
Kinase assay
GST Tag

For Research Use Only. Not for use in diagnostic procedures.