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EGFR (ErbB1) [T790M] [L858R] Recombinant Human Protein, Invitrogen™ DFS Item

The epidermal growth factor receptor is a receptor tyrosine kinases that signals in response to various growth factors.

Manufacturer:  Life Technologies LSPV4880

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Catalog No. PV4880



Description

Description

Overexpression of EGFR has been linked to numerous types of cancer and EGFR is the target of both biological and small molecular therapeutics. The double T790M L858R mutant of EGFR displays resistance to Erlotinib (Tarceva) and sensitivity to HKI-272 and rapamycin combination therapy.

Specifications

Specifications

NP_005219.2; T790M L858R
Frozen
90.6kDa
Store at -80°C. At first use, aliquot and store at -80°C to avoid multiple freeze-thaws.
Cytoplasmic
Kinase Assay
EGF Receptor (ErbB) Kinase Family
Yes
Target & Lead Identification & Validation|Kinase Biology|Biochemical Kinase Assays|Protein Biology|Enzyme & Protein Activity Assays|Kinase Activity|Protein Assays and Analysis|Industrial & Applied Science|Pharma & Biopharma
50mM Tris pH 7.5, 150mM NaCl, 0.5mM EDTA, 0.02% Polysorbate 20, 2mM DTT, 50% glycerol
1mg
RUO - research use only
EGFR (ErbB1) T790M L858R
Baculovirus
Human
GST Tag
Documents