EGFR (ErbB1) [T790M] [L858R] Recombinant Human Protein, Invitrogen™
The epidermal growth factor receptor is a receptor tyrosine kinases that signals in response to various growth factors.
Manufacturer: Life Technologies LSPV4880
Overexpression of EGFR has been linked to numerous types of cancer and EGFR is the target of both biological and small molecular therapeutics. The double T790M L858R mutant of EGFR displays resistance to Erlotinib (Tarceva) and sensitivity to HKI-272 and rapamycin combination therapy.
|NP_005219.2; T790M L858R|
|Store at -80°C. At first use, aliquot and store at -80°C to avoid multiple freeze-thaws.|
|EGF Receptor (ErbB) Kinase Family|
|Target & Lead Identification & Validation|Kinase Biology|Biochemical Kinase Assays|Protein Biology|Enzyme & Protein Activity Assays|Kinase Activity|Protein Assays and Analysis|Industrial & Applied Science|Pharma & Biopharma|
|50mM Tris pH 7.5, 150mM NaCl, 0.5mM EDTA, 0.02% Polysorbate 20, 2mM DTT, 50% glycerol|
|RUO - research use only|
|EGFR (ErbB1) T790M L858R|