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EGFR (ErbB1) [L858R] Recombinant Human Protein, Invitrogen™ DFS Item

EGFR (ErbB1) [L858R] Recombinant Human Protein

Manufacturer:  Life Technologies LSPV4128

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Catalog No. PV4128



Description

Description

The epidermal growth factor receptor is a receptor tyrosine kinases that signals in response to various growth factors. Overexpression has been linked to numerous types of cancer and EGFR is the target of both biological and small molecular therapeutics. The EGFR L858R mutation is implicated in epithelial tumor formation.
Specifications

Specifications

NP_005219.2; L858R
Cell viability, proliferation and function, pharma and biopharma, protein assays and analysis, target and lead identification and validation
90.5kDa
60% by SDS-PAGE
–80°C
1 Each
EGFR (ErbB1) L858R
EGFR (ErbB1) L858R was pre-diluted in enzyme dilution buffer and assayed in 25mM HEPES (pH 7.5), 10mM MgCl2, 1mM EGTA, 0.5mM Na3VO4, 5mM β-glycerophosphate, 2mM DTT, 0.01% Triton™ X-100, 200μM ATP, 200μg/mL poly [Glu, Tyr] 4:1 substrate and trace [32P]- γ-ATP for 10 minutes at 30°C
Kinase and inhibitors
EGF receptor (ErbB)
EGFR (ErbB1) [L858R] Recombinant Human Protein
Human
0.32mg/mL
1956, 7124
EGFR (ErbB1) [L858R] Recombinant Human Protein
10μg
For research use only. Not for use in diagnostic procedures
Receptor tyrosine kinases
EGFR (ErbB1) [L858R] Recombinant Human Protein
Kinase assay
Baculovirus
Amino acids 668-1210: L858R
840nmoles of phosphate transferred to poly [Glu, Tyr] 4:1 substrate per minute per mg of total protein at 30°C. Activity determined at a final protein concentration of 1μg/mL
GST Tag
Documents

For Research Use Only. Not for use in diagnostic procedures.