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Early Endosome Antigen 1 (EEA1) Mouse, Clone: 1G11, eBioscience™

Mouse Monoclonal Antibody

$133.32 - $322.08

Specifications

Antigen Early Endosome Antigen 1 (EEA1)
Clone 1G11
Host Species Murine
Species Reactivity Human, Mouse, Rat
Applications ELISA,Immunocytochemistry,Immunohistochemistry (Formalin/Paraffin),Microscopy,Western Blot
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Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
501122764 Life Technologies
LS14911480
25μg Each for $133.32
501122765 Life Technologies
LS14911482
100μg Each for $322.08
Specifications

Description

The monoclonal antibody 1G11 recognizes human, mouse and rat early endosome antigen 1 (EEA1). EEA1 is a hydrophilic peripheral membrane protein found in the cytosol and present on early endosome membranes. EEA1 is a dimer that is localized to early endosomes via a cysteine-rich zinc-finger-like FYVE domain. EEA1 interacts with Rab5-GTP, syntaxin 6 and syntaxin 13 (SNARES). EEA1 is required for endocytic membrane docking and fusion, which allows for the recycling of receptors from the plasma membrane or their delivery to lysosomes for degradation. In neurons, early endosomes are involved in the recycling of neurotransmitter receptors. Autoantibodies to EEA1 have been found in patients with neurological deficits which result in enhanced excitatory synaptic transmission.
Description & Specifications

Specifications

Early Endosome Antigen 1 (EEA1)
Murine
ELISA,Immunocytochemistry,Immunohistochemistry (Formalin/Paraffin),Microscopy,Western Blot
Unlabeled
Store at 2-8°C.
Monoclonal
0.5mg/mL
1G11
Human, Mouse, Rat
RUO
Purified
Primary
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer