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Early Endosome Antigen 1 (EEA1) Mouse, Clone: 1G11, eBioscience™

Mouse Monoclonal Antibody

$143.55 - $346.55

Specifications

Antigen Early Endosome Antigen 1 (EEA1)
Clone 1G11
Host Species Mouse
Species Reactivity Human, Mouse, Rat
Applications Enzyme Linked Immunosorbent Assay
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

501122764

 
affymetrix
14911480
25μg Each for $143.55

501122765

 
affymetrix
14911482
100μg Each for $346.55
Description & Specifications

Specifications

Antigen Early Endosome Antigen 1 (EEA1)
Clone 1G11
Host Species Mouse
Species Reactivity Human, Mouse, Rat
Applications Enzyme Linked Immunosorbent Assay
Applications Immunocytochemistry
Applications Immunohistochemistry (Formalin/Paraffin)
Applications Microscopy
Applications Western Blotting
Regulatory Status RUO
Conjugate Unlabeled
Format Purified
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.5mg/mL

The monoclonal antibody 1G11 recognizes human, mouse and rat early endosome antigen 1 (EEA1). EEA1 is a hydrophilic peripheral membrane protein found in the cytosol and present on early endosome membranes. EEA1 is a dimer that is localized to early endosomes via a cysteine-rich zinc-finger-like FYVE domain. EEA1 interacts with Rab5-GTP, syntaxin 6 and syntaxin 13 (SNARES). EEA1 is required for endocytic membrane docking and fusion, which allows for the recycling of receptors from the plasma membrane or their delivery to lysosomes for degradation. In neurons, early endosomes are involved in the recycling of neurotransmitter receptors. Autoantibodies to EEA1 have been found in patients with neurological deficits which result in enhanced excitatory synaptic transmission.