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Thermo Scientific™ Lab Vision™ E2F-1 Transcription Factor Ab-6, Mouse Monoclonal Antibody


Ensure accurate, reproducible results in immunohistochemistry, western blotting, immunofluorescence, immunoprecipitation and gel supershift experiments.

Manufacturer: thermo scientific™ lab vision™  MS879P1ABX

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Catalog No. MS879P1ABX

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Description & Specifications

Specifications

Antigen E2F-1 Transcription Factor Ab-6
Applications Immunofluorescence
Applications Immunohistochemistry (Paraffin)
Applications Immunoprecipitation
Applications Western Blotting
Classification Monoclonal
Clone KH95
Concentration 1mg/mL
Conjugate Unlabeled
Cross Reactivity Human
Cross Reactivity Mouse
Format Concentrated
Formulation Ab without BSA/Azide (Frozen)
Host Species Mouse
Immunogen Recombinant human E2F-1 protein
Isotype IgG2a kappa
Quantity 100µL
Regulatory Status RUO
Research Discipline Transcription Regulation
Type Primary

Ensure accurate, reproducible results in immunohistochemistry, western blotting, immunofluorescence, immunoprecipitation and gel supershift experiments with Thermo Scientific™ E2F-1 Transcription Factor Ab-6, Mouse Monoclonal Antibody.

E2F's are DNA-binding proteins that associate with negative regulators, such as the retinoblastoma p107 protein, resulting in an altered rate of gene transcription. E2F-1 also requires DP-1 for efficient DNA-binding and transcription modification. E2F1 is proposed to be involved in several cellular processes that range from tumor suppression, cell cycle progression, and oncogenesis. E2F-1 overexpression can also drive cells into apoptosis. These observations place E2F among a group of apoptosis inducers that includes c-Myc, Adenovirus E1A, and HPV E7 protein.

Host Species: Mouse

Clone: KH95

Isotype: IgG2a/κ

Species Reactivity: Human and Mouse. Does not react with rat. Others not known.

Epitope: aa 342-386

Immunogen: Recombinant human E2F-1 protein

Molecular Weight: ∽60 kDa

Positive Control: HeLa or MAD109 cells, Tonsil or Breast CA

Cellular Localization: Nuclear

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)
  • Western Blotting
  • Immunofluorescence
  • Immunoprecipitation (Native and denatured)
  • Gel Supershift

Note:

USA: RUO; Int'l: RUO