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Thermo Scientific™ Lab Vision™ E2F-1 Transcription Factor Ab-6, Mouse Monoclonal Antibody


Ensure accurate, reproducible results in immunohistochemistry, western blotting, immunofluorescence, immunoprecipitation and gel supershift experiments.

Manufacturer: thermo scientific™ lab vision™  MS879P1ABX

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Catalog No. MS879P1ABX

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Description & Specifications

Specifications

Format Concentrated
Applications Immunofluorescence
Applications Immunohistochemistry (Paraffin)
Applications Immunoprecipitation
Applications Western Blotting
Quantity 100µL
Antigen E2F-1 Transcription Factor Ab-6
Immunogen Recombinant human E2F-1 protein
Isotype IgG2a kappa
Host Species Mouse
Cross Reactivity Human
Cross Reactivity Mouse
Regulatory Status RUO
Clone KH95
Formulation Ab without BSA/Azide (Frozen)
Classification Monoclonal
Conjugate Unlabeled
Research Discipline Transcription Regulation
Type Primary
Concentration 1mg/mL

Ensure accurate, reproducible results in immunohistochemistry, western blotting, immunofluorescence, immunoprecipitation and gel supershift experiments with Thermo Scientific™ E2F-1 Transcription Factor Ab-6, Mouse Monoclonal Antibody.

E2F's are DNA-binding proteins that associate with negative regulators, such as the retinoblastoma p107 protein, resulting in an altered rate of gene transcription. E2F-1 also requires DP-1 for efficient DNA-binding and transcription modification. E2F1 is proposed to be involved in several cellular processes that range from tumor suppression, cell cycle progression, and oncogenesis. E2F-1 overexpression can also drive cells into apoptosis. These observations place E2F among a group of apoptosis inducers that includes c-Myc, Adenovirus E1A, and HPV E7 protein.

Host Species: Mouse

Clone: KH95

Isotype: IgG2a/κ

Species Reactivity: Human and Mouse. Does not react with rat. Others not known.

Epitope: aa 342-386

Immunogen: Recombinant human E2F-1 protein

Molecular Weight: ∽60 kDa

Positive Control: HeLa or MAD109 cells, Tonsil or Breast CA

Cellular Localization: Nuclear

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)
  • Western Blotting
  • Immunofluorescence
  • Immunoprecipitation (Native and denatured)
  • Gel Supershift

Note:

USA: RUO; Int'l: RUO