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Alfa Aesar™ E-64

Selective and irreversible cysteine protease inhibitor

Chemical Identifiers

Chemical Name or Material E-64
CAS 66701-25-5
Molecular Formula C15H27N5O5
Formula Weight 357.40g/mol
MDL Number MFCD00080261
Beilstein 1405664
Synonym trans-Epoxysuccinyl-L-leucylamido(4-guanidino)butane
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Products
Catalog Number Mfr. No. Quantity Price Quantity    

AAJ62933LB0

 
alfa aesar™
J62933-LB0
5mg CALL N/A N/A
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Description & Specifications

Specifications

Quantity 5mg
Color White to Off-white
Quantity 5mg
Optical Rotation +24° (c=1 in 1N HCl)
Sensitivity Light Sensitive
Chemical Name or Material E-64
CAS 66701-25-5
Physical Form Powder
Molecular Formula C15H27N5O5
Formula Weight 357.40g/mol
MDL Number MFCD00080261
Beilstein 1405664
Synonym trans-Epoxysuccinyl-L-leucylamido(4-guanidino)butane
Solubility Information Soluble in DMSO (25mg/ml), or water (20mg/ml)
Recommended Storage −30° to −10°C
RTECS Number RR0390000

Applications
It is used as a broad spectrum cysteine proteinase and calpain activation inhibitor. Additionally, Prevotella intermediate studies report that E-64 blocks the breakdown of methaemoglobin and the oxidation of oxyhaemoglobin by InpA. E-64 has also been used to study excystation in Giardia lamblia. E-64 is an inhibitor of Calpain, cathepsin K and cathepsin S. E-64 is an effective ligand for affinity purification of cysteine proteases. When coupled to a thiolated affinity matrix, binding is no longer irreversible, but specificity is retained

Solubility
Soluble in DMSO (25mg/ml), or water (20mg/ml)

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: -20°C. Keep away from strong acids, strong bases.

Safety and Handling

−30° to −10°C