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Alfa Aesar™ Doxorubicin hydrochloride, 10mg/mL in distilled water, sterile filtered


Quantity 1mL

Manufacturer: alfa aesar™  J67364-XF

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Catalog No. AAJ67364XF

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Description & Specifications

Chemical Identifiers

Quantity 1mL
Chemical Name or Material Doxorubicin hydrochloride
Name Note 10mg/mL in distilled water, sterile-filtered
CAS 25316-40-9
Physical Form Liquid
MDL Number MFCD00077757
Health Hazard 1 Danger
Health Hazard 2 GHS H Statement
H350
May cause cancer.
Health Hazard 3 GHS P Statement
P281-P201-P202-P308+P313-P405-P501a
Use personal protective equipment as required.
Obtain special instructions before use.
Do not handle until all safety precautions have been read and understood.
IF exposed or concerned: Get medical advice/attention.
Store locked up.
Dispose of contents/container in accordance with local/regional/national/international regulations.
Storage Note 1 -30° to -10°C
RTECS Number QI9295900

Specifications

Chemical Name or Material Doxorubicin hydrochloride
CAS 25316-40-9
Name Note 10mg/mL in distilled water, sterile-filtered
MDL Number MFCD00077757

Applications
It acts as an antitumor antibiotic agent that inhibits DNA topoisomerase II and acts as a DNA intercalator that inhibits nucleic acid synthesis and induces apoptosis. It reduces intracellular tau levels. By intercalating within DNA, doxorubicin inhibits nucleic acid synthesis and induces apoptosis by inducing the accumulation of the p53 tumor suppressor protein. It is an is an inhibitor of AMPK, TERT and POLR. its fluorescent property has been exploited for the measurement of drug efflux pump activities as well as resolving the important question of intracellular localization of various multidrug resistance proteins and the role of subcellular organelles (Golgi and lysosome) in the sequestration of drugs and its implication in drug resistant phenotypes. It is applied as an antineoplastic.

Solubility
Fully miscible in water and soluble in 50 mM in DMSO, methanol and isotonic sodium chloride (>10 mg/ml). Insoluble in chloroform, and ether.

Notes
Protect from heat. Keep the container tightly closed and place it in a cool, dry and well ventilated condition. Store in freezer at -20°C.

Accessories

Danger

GHS P Statement
P281-P201-P202-P308+P313-P405-P501a
Use personal protective equipment as required.
Obtain special instructions before use.
Do not handle until all safety precautions have been read and understood.
IF exposed or concerned: Get medical advice/attention.
Store locked up.
Dispose of contents/container in accordance with local/regional/national/international regulations.

GHS H Statement
H350
May cause cancer.

-30° to -10°C