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Disialoganglioside GD3 Mouse anti-Human, Clone: MB3.6, eBioscience™

Mouse Monoclonal Antibody

$129.05 - $346.55

Specifications

Antigen Disialoganglioside GD3
Clone MB3.6
Host Species Mouse
Species Reactivity Human
Applications Immunocytochemistry
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

501122823

 
affymetrix
14975480
25μg Each for $129.05

501122824

 
affymetrix
14975482
100μg Each for $346.55
Description & Specifications

Specifications

Antigen Disialoganglioside GD3
Clone MB3.6
Host Species Mouse
Species Reactivity Human
Applications Immunocytochemistry
Applications Immunohistochemistry (Formalin/Paraffin)
Applications Immunohistochemistry (Frozen)
Applications Microscopy
Regulatory Status RUO
Conjugate Unlabeled
Format Purified
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.5mg/mL

The monoclonal antibody MB3.6 recognizes human disialoganglioside GD3, a membrane-bound sialic acid-containing glycosphingolipid. Gangliosides are synthesized in the Golgi apparatus by glycosyltransferases before localizing to the plasma membrane. Gangliosides function as receptors for growth factors and hormones as well as mediating interaction with adhesion molecules at the surface of all cells. GD3 is expressed at low levels in retina pigment cells and melanocytes. Elevated GD3 levels are found in neural stem cells, epithelial-origin tumor cells (cervical, ovarian, prostate, breast, and skin), as well as T-cell leukemic lymphoblasts (T-ALL). The GD3 monoclonal antibody has been reported to fix complement and induce antibody-dependent cytotoxicity of melanoma cell lines.