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Difluoromethyl phenyl sulfone, 95%, Thermo Scientific Chemicals
Supplier: Thermo Scientific Chemicals H6476006
Description
Used as a reagent for the nucleophilic difluoro(phenylsulfonyl)methylation of carbonyls and fluorination. Reagent used for reductive silylation and the preparation of trifluoro- and difluoromethylsilanes by reductive coupling of fluoromethyl sulfones, sulfoxides and sulfides with chlorosilanes, fluoroalkylation/chloroalkylation of α,β-enones, arynes, acetylenic ketones and other Michael acceptors, difluoromethylation of primary alkyl halides via nucleophilic substitution-reductive desulfonylation. Also used as reagent in preparation of α-difluoromethyl amines via stereo selective (phenylsulfonyl)difluoromethylation of chiral sulfinyl aldimines and Anti-difluoropropanediols via potassium tert-butoxide-catalyzed difluoromethylenation of aldehydes.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
ApplicationsUsed as a reagent for the nucleophilic difluoro(phenylsulfonyl)methylation of carbonyls and fluorination. Reagent used for reductive silylation and the preparation of trifluoro- and difluoromethylsilanes by reductive coupling of fluoromethyl sulfones, sulfoxides and sulfides with chlorosilanes, fluoroalkylation/chloroalkylation of α,β-enones, arynes, acetylenic ketones and other Michael acceptors, difluoromethylation of primary alkyl halides via nucleophilic substitution-reductive desulfonylation. Also used as reagent in preparation of α-difluoromethyl amines via stereo selective (phenylsulfonyl)difluoromethylation of chiral sulfinyl aldimines and Anti-difluoropropanediols via potassium tert-butoxide-catalyzed difluoromethylenation of aldehydes.
Solubility
Soluble in chloroform and water.
Notes
Keep container tightly closed. With adequate ventilation. Store away from oxidizing agent.
Specifications
Difluoromethyl phenyl sulfone | |
24°C to 25°C | |
C7H6F2O2S | |
MFCD01050170 | |
2259218 | |
Soluble in chloroform and water. | |
C1=CC=C(C=C1)S(=O)(=O)C(F)F | |
192.18 | |
192.18 |
1535-65-5 | |
1.324 | |
1.5 | |
5 g | |
difluoromethyl sulfonyl benzene, difluoromethyl phenyl sulfone, difluoromethanesulfonylbenzene, phenyl difluoromethyl sulfone, benzene, difluoromethyl sulfonyl, difluoromethyl sulfonylbenzene, difluoro-methanesulfonyl-benzene, difluoromethyl sulfonyl-benzene | |
LRHDNAVPELLXDL-UHFFFAOYSA-N | |
difluoromethylsulfonylbenzene | |
11816356 | |
95% |
Chemical Identifiers
1535-65-5 | |
192.18 | |
LRHDNAVPELLXDL-UHFFFAOYSA-N | |
11816356 | |
C1=CC=C(C=C1)S(=O)(=O)C(F)F |
C7H6F2O2S | |
MFCD01050170 | |
difluoromethyl sulfonyl benzene, difluoromethyl phenyl sulfone, difluoromethanesulfonylbenzene, phenyl difluoromethyl sulfone, benzene, difluoromethyl sulfonyl, difluoromethyl sulfonylbenzene, difluoro-methanesulfonyl-benzene, difluoromethyl sulfonyl-benzene | |
difluoromethylsulfonylbenzene |
Safety and Handling
GHS H Statement
H315-H319-H335
Causes skin irritation.
Causes serious eye irritation.
May cause respiratory irritation.
P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P362-P501c
H315-H319-H335
TSCA : No
Recommended Storage : Ambient temperatures; Store under Nitrogen
RUO – Research Use Only