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Alfa Aesar™ Diethyl cyanomethylphosphonate, 98+%

Chemical Identifiers

Chemical Name or Material Diethyl cyanomethylphosphonate
CAS 2537-48-6
Molecular Formula C6H12NO3P
Formula Weight 177.14g/mol
MDL Number MFCD00001893
UN Number UN3278
Beilstein 1772981
Synonym Cyanomethylphosphonic acid diethyl ester; Diethyl phosphonoacetonitrile
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Products
Catalog Number Mfr. No. Quantity Price Quantity    

AAA1021822

 
alfa aesar™
A10218-22
100g CALL N/A N/A
 Please call Customer Service at 1-800-234-7437 or send an email to help@thermofisher.com for assistance.

AAA1021836

 
alfa aesar™
A10218-36
500g CALL N/A N/A
 Please call Customer Service at 1-800-234-7437 or send an email to help@thermofisher.com for assistance.
Description & Specifications

Specifications

Boiling Point 132° to 135°C (1.2mmHg)
Flash Point >110°C (230°F)
Quantity 100g
Chemical Name or Material Diethyl cyanomethylphosphonate
CAS 2537-48-6
Assay ≥98%
Molecular Formula C6H12NO3P
Formula Weight 177.14g/mol
MDL Number MFCD00001893
UN Number UN3278
Beilstein 1772981
Synonym Cyanomethylphosphonic acid diethyl ester; Diethyl phosphonoacetonitrile
Health Hazard 1 Danger
Health Hazard 2 GHS H Statement
H331-H302-H312-H315-H319
Toxic if inhaled.
Harmful if swallowed.
Harmful in contact with skin.
Causes skin irritation.
Causes serious eye irritation.
Health Hazard 3 GHS P Statement
P261-P280-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapors/spray.
Wear protective gloves/protective clothing/eye protection/face protection.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do.
Continue rinsing.
IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing.
Store locked up.
Dispose of contents/container in accordance with local/regional/national/international regulations.
DOT Information Transport Hazard Class: 6.1; Packing Group: III; Proper Shipping Name: ORGANOPHOSPHORUS COMPOUND, LIQUID, TOXIC, N.O.S.

Applications
Diethyl cyanomethyl phosphonate is used as an intermediate in Horner-Emmons reaction for the synthesis of substituted nitriles and their amide and heterocyclic derivatives. It is known as a modified Wittig reagent used in the preparation of alpha, beta-unsaturated nitriles from ketones or aldehydes like 3-hydroxy-3-methylbutanal. It reacts with epoxides and nitrones to prepare cyano-substituted cyclopropanes and aziridines respectively. It is actively involved in the synthesis of alpha-arylated alkanenitriles via reaction with aryl iodides in presence of CuI.

Solubility
Miscible with water, chloroform, terahydrofuran, ethyl acetate and methylene chloride.

Notes
Incompatible with acids, bases, oxidizing agents and reducing agents.

Safety and Handling

Danger

GHS P Statement
P261-P280-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapors/spray.
Wear protective gloves/protective clothing/eye protection/face protection.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do.
Continue rinsing.
IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing.
Store locked up.
Dispose of contents/container in accordance with local/regional/national/international regulations.

GHS H Statement
H331-H302-H312-H315-H319
Toxic if inhaled.
Harmful if swallowed.
Harmful in contact with skin.
Causes skin irritation.
Causes serious eye irritation.