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Desmin Mouse, Clone: DE-U-10, eBioscience™

Mouse Monoclonal Antibody

$158.05 - $419.05

Specifications

Antigen Desmin
Clone DE-U-10
Host Species Mouse
Species Reactivity Bovine, cat, Chicken, Goat, Hamster, Human, Mouse, Pig, Rabbit, Rat, Sheep
Applications Immunocytochemistry
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 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

501122815

 
affymetrix
14974780
25μg Each for $158.05

501122816

 
affymetrix
14974782
100μg Each for $419.05
Description & Specifications

Specifications

Antigen Desmin
Clone DE-U-10
Host Species Mouse
Species Reactivity Bovine, cat, Chicken, Goat, Hamster, Human, Mouse, Pig, Rabbit, Rat, Sheep
Applications Immunocytochemistry
Applications Immunohistochemistry (Formalin/Paraffin)
Applications Microscopy
Applications Western Blotting
Regulatory Status RUO
Conjugate Unlabeled
Format Purified
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.5mg/mL

The monoclonal antibody DE-U-10 recognizes desmin. Desmin is the protein subunit of class-III intermediate filaments. Desmin is found predominantly in skeletal, cardiac, and smooth muscle. Desmin plays a role in muscle cell development and differentiation, muscle cell architecture and structure, and mitochondrial function. Desmin forms scaffolds around the Z-disk of sarcomeres in muscle cells. Desmin knockout mice exhibit defects in skeletal, smooth, and cardiac muscle and have impaired mitochondrial function. Mutations in Desmin result in conditions such as desmin-related myopathy (DRM), cardiomyopathy dilated type 1I (CMD1I), and neurogenic scapuloperoneal syndrome Kaeser type (Kaeser syndrome).

The DE-U-10 antibody recognizes human, mouse, rat, feline, bovine, goat, hamster, sheep, porcine, rabbit, and chicken desmin. The DE-U-10 antibody will also label tumors derived from muscle tissue, such as leiomyomas and rhabdomyosarcomas.