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Delta-like 4 Functional Grade Armenian Hamster anti-Mouse, Clone: HMD4-1, Functional Grade, eBioscience™

Armenian Hamster Monoclonal Antibody, Functional Grade

$187.05 - $404.55

Specifications

Antigen Delta-like 4 Functional Grade
Clone HMD4-1
Host Species Armenian Hamster
Gene Alias DLL4
Species Reactivity Mouse, Rat
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 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

50245627

 
affymetrix
16594882
100μg Each for $187.05

50245628

 
affymetrix
16594885
500μg Each for $404.55
Description & Specifications

Specifications

Antigen Delta-like 4 Functional Grade
Clone HMD4-1
Host Species Armenian Hamster
Gene Alias DLL4
Species Reactivity Mouse, Rat
Applications Functional Assay
Regulatory Status RUO
Conjugate Unlabeled
Format Purified
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, no sodium azide
Concentration 1mg/mL

This HMD4-1 monoclonal antibody reacts with the extracellular domain of mouse Delta-like 4, one of five type I transmembrane proteins that serves as a Notch receptor ligand. Upon binding the Notch receptor (e.g., Notch 1-4), Delta-like 4 undergoes proteolytic cleavage, first by ADAM-family metalloproteases and then by gamma-secretase. The second cleavage event releases the Notch intracellular domain (NICD), which subsequently translocates into the nucleus, heterodimerizes with the DNA-binding protein RBP-J, recruits co-activator molecules, and ultimately activates transcription. Delta-like 4 is expressed by thymic lymphoid and stromal cells, as well as macrophages and dendritic cells in the spleen. This molecule is also expressed in non-immune cells, including vascular smooth muscle and endothelial cells. Delta-like 4 plays a role in T cell development, regulation of experimental autoimmune encephalomyelitis, and the formation of mature vasculature.

The HMD4-1 monoclonal antibody has been reported to have blocking activity and crossreact to rat.