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Cytarabine, 98%, Thermo Scientific™

Cytarabine, CAS # 147-94-4, is an inhibitor of DNA synthesis that is used as an anticancer and antiviral agent.

Manufacturer:  Thermo Fisher Scientific AC449560010

Catalog No. AC449560010

Please call Customer Service at 1-800-234-7437 or send an email to help@thermofisher.com for assistance.


Description

Description

This Thermo Scientific brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific.

General Description
Cytarabine is a nucleoside analog that acts as an antileukemic agent
Cytarabine becomes cytotoxic following conversion to its triphosphorylated form, which can be incorporated into DNA primers by DNA polymerase alpha
Can induce S phase cell cycle arrest and apoptosis in leukemic and neuronal cells
Applications
Has been used to study chemotherapeutic regimens in laboratory studies of leukemia
Useful for laboratory studies of cytarabine resistance mechanisms
At nanomolar concentrations, cytarabine has been seen to induce mitochondrial apoptosis in leukemic cells through upregulation of multiple Bcl-2 family members
It can induce neuronal cell death via inducing γ-H2AX phosphorylation in histones, in the absence of double-stranded DNA breaks
Specifications

Specifications

Cytarabine
220.0°C
C9H13N3O5
152781
1g
UHDGCWIWMRVCDJ-CCXZUQQUSA-N
4-amino-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one
6253
243.22
147-94-4
97.5% min. (HPLC)
Glass bottle
ara-c, arabinocytidine, arabinosylcytosine, aracytidine, cytarabin, cytarabine, cytarabinoside, cytosar, cytosine arabinoside, tarabine
Solubility in water: soluble. Other solubilities: soluble in dmso, ethanol
C1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)O
243.22
CHEBI:28680
98%
Safety and Handling

Safety and Handling

Causes serious eye irritation, Suspected of causing genetic defects, Suspected of damaging fertility or the unborn child, May cause an allergic skin reaction

Serious eye damage/eye irritation (category 2), Germ cell mutagenicity (category 2), Reproductive toxicity (category 2), Skin sensitisation (category 1)

EINECSNumber : 205-705-9

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RUO – Research Use Only