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Cytarabine, 98%, Thermo Scientific Chemicals
Cytarabine, CAS # 147-94-4, is an inhibitor of DNA synthesis that is used as an anticancer and antiviral agent.
$73.94 - $73.94
Chemical Identifiers
| CAS | 147-94-4 |
|---|---|
| Molecular Formula | C9H13N3O5 |
| Molecular Weight (g/mol) | 243.22 |
| InChI Key | UHDGCWIWMRVCDJ-CCXZUQQUSA-N |
| Synonym | cytarabine, cytosine arabinoside, ara-c, arabinocytidine, cytosar, arabinosylcytosine, aracytidine, cytarabin, cytarabinoside, tarabine |
| PubChem CID | 6253 |
| ChEBI | CHEBI:28680 |
| IUPAC Name | 4-amino-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one |
| SMILES | C1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)O |
| Catalog Number | Mfr. No. | Quantity | Packaging | Price | Quantity | ||||
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| Catalog Number | Mfr. No. | Quantity | Packaging | Price | Quantity | ||||
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AC449561000
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Thermo Scientific Chemicals
449561000 |
100 mg | Glass bottle |
Each for $73.94
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Description
This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
Cytarabine is a nucleoside analog that acts as an antileukemic agent
Cytarabine becomes cytotoxic following conversion to its triphosphorylated form, which can be incorporated into DNA primers by DNA polymerase alpha
Can induce S phase cell cycle arrest and apoptosis in leukemic and neuronal cells
Applications
Has been used to study chemotherapeutic regimens in laboratory studies of leukemia
Useful for laboratory studies of cytarabine resistance mechanisms
At nanomolar concentrations, cytarabine has been seen to induce mitochondrial apoptosis in leukemic cells through upregulation of multiple Bcl-2 family members
It can induce neuronal cell death via inducing γ-H2AX phosphorylation in histones, in the absence of double-stranded DNA breaks
Chemical Identifiers
| 147-94-4 | |
| 243.22 | |
| cytarabine, cytosine arabinoside, ara-c, arabinocytidine, cytosar, arabinosylcytosine, aracytidine, cytarabin, cytarabinoside, tarabine | |
| CHEBI:28680 | |
| C1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)O |
| C9H13N3O5 | |
| UHDGCWIWMRVCDJ-CCXZUQQUSA-N | |
| 6253 | |
| 4-amino-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one |
Specifications
| 147-94-4 | |
| 97.5% min. (HPLC) | |
| C9H13N3O5 | |
| 152781 | |
| Solubility in water: soluble. Other solubilities: soluble in dmso, ethanol | |
| C1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)O | |
| 243.22 | |
| CHEBI:28680 | |
| 98% |
| 220.0°C | |
| Glass bottle | |
| 100 mg | |
| cytarabine, cytosine arabinoside, ara-c, arabinocytidine, cytosar, arabinosylcytosine, aracytidine, cytarabin, cytarabinoside, tarabine | |
| UHDGCWIWMRVCDJ-CCXZUQQUSA-N | |
| 4-amino-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one | |
| 6253 | |
| 243.22 | |
| Cytarabine |
Safety and Handling
Causes serious eye irritation, Suspected of causing genetic defects, Suspected of damaging fertility or the unborn child, May cause an allergic skin reaction
Serious eye damage/eye irritation (category 2), Germ cell mutagenicity (category 2), Reproductive toxicity (category 2), Skin sensitisation (category 1)
EINECSNumber : 205-705-9
RUO – Research Use Only