Cytokeratin 19 Mouse anti-Human, Alexa Fluor® 488, Clone: BA17, eBioscience™
Mouse Monoclonal Antibody
Manufacturer: Life Technologies LS53989880
Description: This BA17 monoclonal antibody reacts with human cytokeratin 19 (CK19), a 44-kDa type I (acidic) intermediate filament protein that lacks the non-alpha-helical tail domain present in other keratins. Cytokeratins form the intracellular cytoskelCytokeratin 19 is part of a subfamily of intermediate filament proteins and are characterized by a remarkable biochemical diversity, represented in human epithelial tissues by at least 20 different polypeptides. Cytokeratins range in molecular weight from 40-68 kDa and isoelectric pH between 4.9 - 7.8. The individual human cytokeratins are numbered 1 to 20. The various epithelia in the human body usually express cytokeratins which are not only characteristic of the type of epithelium, but also related to the degree of maturation or differentiation within an epithelium. Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial maligcies. The cytokeratin antibodies are not only of assistance in the differential diagnosis of tumors using immunohistochemistry on tissue sections, but are also a useful tool in cytopathology and flow cytometric assays. For example, cytokeratin 19 is not expressed in hepatocytes, therefore, it is useful in the identification of liver metastasis.
|PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2|
|CK-19, Keratin-19, K19|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry|
|Alexa Fluor® 488|
|4° C, store in dark, DO NOT FREEZE!|
For Research Use Only.