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Thermo Scientific™ Lab Vision™ Cytokeratin 16 Ab-1, Mouse Monoclonal Antibody


Ensure accurate, reproducible results in immunohistochemistry and immunofluorescence experiments with Thermo Scientific™ Cytokeratin 16 Ab-1, Mouse Monoclonal Antibody.

Manufacturer: thermo scientific™ lab vision™  MS620P1ABX

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Catalog No. MS620P1ABX

  • / Each
 

Description & Specifications

Specifications

Antigen Cytokeratin 16 Ab-1
Applications Immunofluorescence
Applications Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone LL025
Concentration 1mg/mL
Conjugate Unlabeled
Cross Reactivity Human
Format Concentrated
Formulation Ab without BSA/Azide (Frozen)
Host Species Murine
Immunogen A synthetic peptide from the C-terminus of human cytokeratin 16
Isotype IgG1
Quantity 100μL
Regulatory Status RUO
Research Discipline Cytoskeletal Protein
Type Primary
Monoclonal or Polyclonal Monoclonal
Target Species Human

Ensure accurate, reproducible results in immunohistochemistry and immunofluorescence experiments with Thermo Scientific™ Cytokeratin 16 Ab-1, Mouse Monoclonal Antibody.

Keratins 6 and 16 are expressed in keratinocytes that are undergoing rapid turnover in the suprabasal region (also known as hyperproliferation-related keratins). Keratin 16 is absent in normal breast tissue and in noninvasive breast carcinomas. Only 10% of the invasive breast carcinomas show diffuse or focal positivity. Reportedly, a relatively high concordance was found between the carcinomas immunostaining with the basal cell and the hyperproliferation-related keratins, but not between these markers and the proliferation marker Ki-67. This supports the conclusion that basal cells in breast cancer may show extensive proliferation, and that absence of Ki-67 staining does not mean that (tumor) cells are not proliferating.

Host Species: Mouse

Clone: LL025

Isotype: IgG1

Species Reactivity: Human. Does not react with rat. Others not known.

Epitope: C-terminal

Immunogen: A synthetic peptide from the C-terminus of human cytokeratin 16

Molecular Weight: 48 kDa

Positive Control: Squamous cell CA

Cellular Localization: Cytoplasmic

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)
  • Immunofluorescence

Note:

USA: RUO; Int'l: RUO