Thermo Scientific™ Lab Vision™ Cytokeratin 16 Ab-1, Mouse Monoclonal Antibody
Ensure accurate, reproducible results in immunohistochemistry and immunofluorescence experiments with Thermo Scientific™ Cytokeratin 16 Ab-1, Mouse Monoclonal Antibody.
Manufacturer: Thermo Scientific™ Lab Vision™ MS620P1ABX
Ensure accurate, reproducible results in immunohistochemistry and immunofluorescence experiments with Thermo Scientific™ Cytokeratin 16 Ab-1, Mouse Monoclonal Antibody.Keratins 6 and 16 are expressed in keratinocytes that are undergoing rapid turnover in the suprabasal region (also known as hyperproliferation-related keratins). Keratin 16 is absent in normal breast tissue and in noninvasive breast carcinomas. Only 10% of the invasive breast carcinomas show diffuse or focal positivity. Reportedly, a relatively high concordance was found between the carcinomas immunostaining with the basal cell and the hyperproliferation-related keratins, but not between these markers and the proliferation marker Ki-67. This supports the conclusion that basal cells in breast cancer may show extensive proliferation, and that absence of Ki-67 staining does not mean that (tumor) cells are not proliferating.
Host Species: Mouse
Species Reactivity: Human. Does not react with rat. Others not known.
Immunogen: A synthetic peptide from the C-terminus of human cytokeratin 16
Molecular Weight: 48 kDa
Positive Control: Squamous cell CA
Cellular Localization: Cytoplasmic
- Immunohistochemistry (Formalin/paraffin)
USA: RUO; Int'l: RUO
|Cytokeratin 16 Ab-1|
|Ab without BSA/Azide (Frozen)|
|A synthetic peptide from the C-terminus of human cytokeratin 16|