Thermo Scientific™ Lab Vision™ Cystic Fibrosis Transmembrane Regulator (CFTR) Ab-4, Mouse Monoclonal Antibody
Obtain accurate, reproducible results in immunohistochemistry, immunofluorescence and immunoprecipitation experiments.
Manufacturer: Thermo Scientific™ Lab Vision™ MS1249P1ABX
Obtain accurate, reproducible results in immunohistochemistry, immunofluorescence and immunoprecipitation experiments with Thermo Scientific™ Cystic Fibrosis Transmembrane Regulator (CFTR) Ab-4, Mouse Monoclonal Antibody.CFTR (cystic fibrosis transmembrane conductance regulator) is composed of two membrane-spanning domains (MSD), two nucleotide-binding domains (NBD), and an R domain. It is structurally similar to multidrug resistance (Mdr1) protein and both are members of the superfamily of ATP-binding cassette (ABC) transporters, also known as traffic ATPases, which are implicated in the movement of various substrates. The CFTR protein is a small conductance adenosine 3',5'-cyclic monophosphate (cAMP)-activated chloride ion channel found in the apical membranes of epithelia within the pancreas, airway, intestine, bile duct, sweat gland, and male genital ducts. CFTR is a valuable marker of human pancreatic duct cell development and differentiation.
Host Species: Mouse
Species Reactivity: Human, Mouse and Rat. Others not known.
Epitope: aa 1370-1380
Immunogen: Recombinant protein encoding NBF2 domain of human CFTR
Molecular Weight: 165-170 kDa
Positive Control: Pancreas
Cellular Localization: Membrane
- Immunohistochemistry (Formalin/paraffin)
- Western Blotting (Not verified)
USA: RUO; Int'l: RUO
|Cystic Fibrosis Transmembrane Regulator (CFTR) Ab-4|
|Ab without BSA/Azide (Frozen)|
|Recombinant protein encoding NBF2 domain of human CFTR|