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Thermo Scientific™ Cystic Fibrosis Transmembrane Regulator (CFTR) Ab-3, Mouse Monoclonal Antibody


Ensure accurate, reproducible results in immunofluorescence and immunoprecipitation experiments.

Manufacturer: thermo scientific™  MS1248PABX

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Catalog No. MS1248PABX

  • / Each
 

Description & Specifications

Specifications

Host Species Mouse
Applications Immunofluorescence
Applications Immunoprecipitation
Immunogen Recombinant protein encoding NBF1 domain of human CFTR
Isotype IgG1
Cross Reactivity Human
Cross Reactivity Mouse
Cross Reactivity Rat
Antigen Cystic Fibrosis Transmembrane Regulator (CFTR) Ab-3
Format Concentrated
Quantity 200µL
Regulatory Status RUO
Clone L12B4
Classification Monoclonal
Conjugate Unlabeled
Type Primary
Concentration 1mg/mL

Ensure accurate, reproducible results in immunofluorescence and immunoprecipitation experiments with Thermo Scientific™ Cystic Fibrosis Transmembrane Regulator (CFTR) Ab-3, Mouse Monoclonal Antibody.

CFTR (cystic fibrosis transmembrane conductance regulator) is composed of two membrane-spanning domains (MSD), two nucleotide-binding domains (NBD), and an R domain. It is structurally similar to multidrug resistance (Mdr1) protein and both are members of the superfamily of ATP-binding cassette (ABC) transporters, also known as traffic ATPases, which are implicated in the movement of various substrates. The CFTR protein is a small conductance adenosine 3',5'-cyclic monophosphate (cAMP)-activated chloride ion channel found in the apical membranes of epithelia within the pancreas, airway, intestine, bile duct, sweat gland, and male genital ducts. CFTR is a valuable marker of human pancreatic duct cell development and differentiation.

Host Species: Mouse

Clone: L12B4

Isotype: IgG1

Species Reactivity: Human, Mouse and Rat. Others not known.

Epitope: aa 386-412

Immunogen: Recombinant protein encoding NBF1 domain of human CFTR

Molecular Weight: 165-170 kDa

Positive Control: Pancreas

Cellular Localization: Membrane

Recommended for:

  • Western Blotting (Not verified)
  • Immunofluorescence
  • Immunoprecipitation

Note:

USA: RUO; Int'l: RUO