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Cyclosporin A, 99+%, Thermo Scientific Chemicals
Cyclosporin A, CAS # 59865-13-3, is a compound that shows immunosuppressive, antifungal, antirheumatic, and dermatologic activities. It is also a calcineurin and enzyme inhibitor.
Supplier: Thermo Scientific Chemicals J6319106
Description
Ciclosporin A induces apoptosis and inhibits angiogenesis induced by VEGF. It also suppresses the replication of hepatitis C virus genome in cultured hepatocytes.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
• Cyclosporin A is a non-polar cyclic oligopeptide produced by the fungus Tolypocladium inflatum
Applications
• It inhibits phosphoprotein phosphatase
• Cyclosporin A binds to the cellular protein cytophilin and inhibits the enzyme calcineurin
• Furthermore, it can induce apoptosis and inhibit angiogenesis induced by VEGF
• It exerts potent immunosuppressive activity on T immune cells, and causes reversible inhibition of immunocompetent lymphocytes in the G0- and G1-phase of the cell cycle
• It also suppresses the hepatitis C virus replication in cultured hepatocytes
Specifications
| Cyclosporin A | |
| Crystalline Solid | |
| 146°C to 151°C | |
| MFCD00274558 | |
| 14,2752 | |
| Soluble in dimethyl sulfoxide and ethanol; Insoluble in water. | |
| CCC1NC(=O)C(C(O)C(C)C\C=C\C)N(C)C(=O)C(C(C)C)N(C)C(=O)C(CC(C)C)N(C)C(=O)C(CC(C)C)N(C)C(=O)C(C)NC(=O)C(C)NC(=O)C(CC(C)C)N(C)C(=O)C(NC(=O)C(CC(C)C)N(C)C(=O)CN(C)C1=O)C(C)C | |
| 1202.64 | |
| 1202.61 | |
| White |
| Cyclosporin A | |
| 59865-13-3 | |
| C62H111N11O12 | |
| 3647785 | |
| Cyclosporine A; Antibiotic S 7481F1 | |
| PMATZTZNYRCHOR-IMVLJIQENA-N | |
| 30-ethyl-33-[(4E)-1-hydroxy-2-methylhex-4-en-1-yl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-bis(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecone | |
| 132274082 | |
| ≥99% | |
| 5 g |
Chemical Identifiers
| 59865-13-3 | |
| 1202.64 | |
| PMATZTZNYRCHOR-IMVLJIQENA-N | |
| 132274082 | |
| CCC1NC(=O)C(C(O)C(C)C\C=C\C)N(C)C(=O)C(C(C)C)N(C)C(=O)C(CC(C)C)N(C)C(=O)C(CC(C)C)N(C)C(=O)C(C)NC(=O)C(C)NC(=O)C(CC(C)C)N(C)C(=O)C(NC(=O)C(CC(C)C)N(C)C(=O)CN(C)C1=O)C(C)C |
| C62H111N11O12 | |
| MFCD00274558 | |
| Cyclosporine A; Antibiotic S 7481F1 | |
| 30-ethyl-33-[(4E)-1-hydroxy-2-methylhex-4-en-1-yl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-bis(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecone |
Safety and Handling
GHS H Statement
H361-H302
Suspected of damaging fertility or the unborn child.
Harmful if swallowed.
P201-P202-P264b-P270-P281-P301+P312-P308+P313-P330-P501c
H302-H350-H360FD
EINECSNumber : 611-907-1
RTECSNumber : GZ4120000
TSCA : No
Recommended Storage : Store at -20°C
RUO – Research Use Only