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Alfa Aesar™ Cyclopamine, 99+%

$374.73 - $663.11

Chemical Identifiers

CAS 4449-51-8
Molecular Formula C27H41NO2
Molecular Weight (g/mol) 411.63
MDL Number MFCD01735266
InChI Key QASFUMOKHFSJGL-VHSWPJJGSA-N
Synonym cyclopamine, 3b,23b-17,23-epoxy-11-deoxoveratraman-3-ol
PubChem CID 122130428
IUPAC Name (3S,3'R,3'aS,6'S,6aS,9S)-3',6',10,11b-tetramethylspiro[2,3,4,6,6a,6b,7,8,11,11a-decahydro-1H-benzo[a]fluorene-9,2'-3a,4,5,6,7,7a-hexahydro-3H-furo[3,2-b]pyridine]-3-ol
SMILES CC1CC2C(C(C3(O2)CCC4C5CC=C6CC(CCC6(C5CC4=C3C)C)O)C)NC1
View More Specs

Products 2
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
AAJ61528MB View Documents Alfa Aesar™
J61528MB
25mg Each for $374.73
 
AAJ61528MF View Documents Alfa Aesar™
J61528MF
50mg Each for $663.11
 
Description

Description

Applications
Cyclopamine, is used as a hedgehog [Hh] signaling pathway and Smo inhibitor. It depletes stem-like cancer cells in glioblastoma and blocks tumor engraftment. Can also be used to induce differentiation of human embryonic stem cells (hESCs) into hormone-expressing endocrine cells.

Solubility
Soluble in ethanol (5 mg/ml warm), DMSO (4 mg/ml), DMF (10 mg/ml), methylene chloride, chloroform, methanol (7 mg/ml), and benzene.

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: 2 - 8°C. Keep away from strong oxidizing agents.
Specifications

Chemical Identifiers

4449-51-8
411.63
QASFUMOKHFSJGL-VHSWPJJGSA-N
122130428
CC1CC2C(C(C3(O2)CCC4C5CC=C6CC(CCC6(C5CC4=C3C)C)O)C)NC1
C27H41NO2
MFCD01735266
cyclopamine, 3b,23b-17,23-epoxy-11-deoxoveratraman-3-ol
(3S,3'R,3'aS,6'S,6aS,9S)-3',6',10,11b-tetramethylspiro[2,3,4,6,6a,6b,7,8,11,11a-decahydro-1H-benzo[a]fluorene-9,2'-3a,4,5,6,7,7a-hexahydro-3H-furo[3,2-b]pyridine]-3-ol

Specifications

White
25mg
C27H41NO2
cyclopamine, 3b,23b-17,23-epoxy-11-deoxoveratraman-3-ol
CC1CC2C(C(C3(O2)CCC4C5CC=C6CC(CCC6(C5CC4=C3C)C)O)C)NC1
411.63
411.62
≥99%
234°C to 237°C
4449-51-8
MFCD01735266
QASFUMOKHFSJGL-VHSWPJJGSA-N
(3S,3'R,3'aS,6'S,6aS,9S)-3',6',10,11b-tetramethylspiro[2,3,4,6,6a,6b,7,8,11,11a-decahydro-1H-benzo[a]fluorene-9,2'-3a,4,5,6,7,7a-hexahydro-3H-furo[3,2-b]pyridine]-3-ol
122130428
Powder
Cyclopamine
Safety and Handling

Safety and Handling

GHS H Statement
H341-H361
Suspected of causing genetic defects.
Suspected of damaging fertility or the unborn child.

GHS P Statement
P281-P201-P202-P308+P313-P405-P501a
Use personal protective equipment as required.
Obtain special instructions before use.
Do not handle until all safety precautions have been read and understood.
IF exposed or concerned: Get medical advice/attention.
Store locked up.
Dispose of contents/container in accordance with local/regional/national/international regulations.

Warning

RTECSNumber : GY0750000

Recommended Storage : −30° to −10°C