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Thermo Scientific™ Lab Vision™ Cyclin E Ab-1, Rabbit Polyclonal Antibody


Ensure accurate, reproducible results in western blotting, immunofluorescence, immunoprecipitation and kinase assay experiments.

Manufacturer: thermo scientific™ lab vision™  RB012P1ABX

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Catalog No. RB012P1ABX

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Description & Specifications

Specifications

Antigen Cyclin E Ab-1
Applications Immunoprecipitation
Applications Western Blotting
Classification Polyclonal
Concentration 1mg/mL
Conjugate Unlabeled
Cross Reactivity Human
Format Concentrated
Formulation Ab without BSA/Azide (Frozen)
Host Species Rabbit
Immunogen A synthetic peptide derived from the C-terminus of human cyclin E
Isotype IgG
Quantity 500μL
Regulatory Status RUO
Research Discipline Cell Cycle
Type Primary
Monoclonal or Polyclonal Polyclonal
Target Species Human

Ensure accurate, reproducible results in western blotting, immunofluorescence, immunoprecipitation and kinase assay experiments with Thermo Scientific™ Cyclin E Ab-1, Rabbit Polyclonal Antibody.

Cyclin E is a regulatory subunit of cdk-2 and controls G1/S transition during the mammalian cell cycle. Multiple isoforms of cyclin E are expressed only in tumors but not in the normal tissues, suggesting a post-transcriptional regulation of cyclin E. In vitro analyses indicated that these truncated variant isoforms of cyclin E are able to phosphorylate histone H1. Alterations in cyclin E protein have been implicated as indicators of worse prognosis in various cancers.

Host Species: Rabbit

Isotype: IgG

Species Reactivity: Human and Mouse. Others not known.

Epitope: C-terminal

Immunogen: A synthetic peptide derived from the C-terminus of human cyclin E

Molecular Weight: 50 kDa (in normal tissues), and up to 12 proteins ranging 20-50 kDa (in tumor samples)

Positive Control: SKBR3 and MAD109 cells

Cellular Localization: Nuclear

Recommended for:

  • Western Blotting
  • Immunofluorescence
  • Immunoprecipitation (Native and denatured)
  • Kinase Assay

Note:

USA: RUO; Int'l: RUO