Thermo Scientific™ Lab Vision™ Cyclin E Ab-1, Rabbit Polyclonal Antibody
Ensure accurate, reproducible results in western blotting, immunofluorescence, immunoprecipitation and kinase assay experiments.
Manufacturer: Thermo Scientific™ Lab Vision™ RB012P1ABX
Ensure accurate, reproducible results in western blotting, immunofluorescence, immunoprecipitation and kinase assay experiments with Thermo Scientific™ Cyclin E Ab-1, Rabbit Polyclonal Antibody.Cyclin E is a regulatory subunit of cdk-2 and controls G1/S transition during the mammalian cell cycle. Multiple isoforms of cyclin E are expressed only in tumors but not in the normal tissues, suggesting a post-transcriptional regulation of cyclin E. In vitro analyses indicated that these truncated variant isoforms of cyclin E are able to phosphorylate histone H1. Alterations in cyclin E protein have been implicated as indicators of worse prognosis in various cancers.
Host Species: Rabbit
Species Reactivity: Human and Mouse. Others not known.
Immunogen: A synthetic peptide derived from the C-terminus of human cyclin E
Molecular Weight: 50 kDa (in normal tissues), and up to 12 proteins ranging 20-50 kDa (in tumor samples)
Positive Control: SKBR3 and MAD109 cells
Cellular Localization: Nuclear
- Western Blotting
- Immunoprecipitation (Native and denatured)
- Kinase Assay
USA: RUO; Int'l: RUO
|Cyclin E Ab-1|
|A synthetic peptide derived from the C-terminus of human cyclin E|
|Ab without BSA/Azide (Frozen)|