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Thermo Scientific™ Lab Vision™ Cyclin E Ab-1, Rabbit Polyclonal Antibody


Ensure accurate, reproducible results in western blotting, immunofluorescence, immunoprecipitation and kinase assay experiments.

Manufacturer: thermo scientific™ lab vision™  RB012P1ABX

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Catalog No. RB012P1ABX

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Description & Specifications

Specifications

Antigen Cyclin E Ab-1
Applications Immunoprecipitation
Applications Western Blotting
Classification Polyclonal
Concentration 1mg/mL
Conjugate Unlabeled
Cross Reactivity Human
Format Concentrated
Formulation Ab without BSA/Azide (Frozen)
Host Species Rabbit
Immunogen A synthetic peptide derived from the C-terminus of human cyclin E
Isotype IgG
Quantity 500µL
Regulatory Status RUO
Research Discipline Cell Cycle
Type Primary

Ensure accurate, reproducible results in western blotting, immunofluorescence, immunoprecipitation and kinase assay experiments with Thermo Scientific™ Cyclin E Ab-1, Rabbit Polyclonal Antibody.

Cyclin E is a regulatory subunit of cdk-2 and controls G1/S transition during the mammalian cell cycle. Multiple isoforms of cyclin E are expressed only in tumors but not in the normal tissues, suggesting a post-transcriptional regulation of cyclin E. In vitro analyses indicated that these truncated variant isoforms of cyclin E are able to phosphorylate histone H1. Alterations in cyclin E protein have been implicated as indicators of worse prognosis in various cancers.

Host Species: Rabbit

Isotype: IgG

Species Reactivity: Human and Mouse. Others not known.

Epitope: C-terminal

Immunogen: A synthetic peptide derived from the C-terminus of human cyclin E

Molecular Weight: 50 kDa (in normal tissues), and up to 12 proteins ranging 20-50 kDa (in tumor samples)

Positive Control: SKBR3 and MAD109 cells

Cellular Localization: Nuclear

Recommended for:

  • Western Blotting
  • Immunofluorescence
  • Immunoprecipitation (Native and denatured)
  • Kinase Assay

Note:

USA: RUO; Int'l: RUO