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Cutaneous Lymphocyte Antigen Rat anti-Human, eFluor 660, Clone: HECA-452, eBioscience™

Rat Monoclonal Antibody

$120.12 - $303.60

Specifications

Antigen Cutaneous Lymphocyte Antigen
Clone HECA-452
Host Species Rat
Species Reactivity Human
Applications Flow Cytometry,Functional Assay,Immunohistochemistry (Formalin/Paraffin),Western Blot
View More Specs

Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
501124562 Life Technologies
LS50985780
25μg Each for $120.12
501124563 Life Technologies
LS50985782
100μg Each for $303.60
Specifications

Description

This HECA-452 monoclonal antibody reacts with human Cutaneous Lymphocyte Antigen (CLA). This cell surface glycoprotein is most highly expressed on T cells in the skin. Nevertheless, CLA can also be detected on some peripheral T and NK cells, as well as monocytes, neutrophils and CD1a+ dendritic cells. Studies have determined that this antibody recognizes sialofucosylated glycans and sialyl Lewis x (sLex). CLA, which binds E-selectin and endothelial cell-leukocyte adhesion molecule 1 (ELAM-1), is involved in T lymphocyte infiltration and adhesion at cutaneous sites of inflammation.

The HECA-452 antibody has been reported to inhibit sLex binding to E-selectin; however, this property is still under debate in the literature.
Description & Specifications

Specifications

Cutaneous Lymphocyte Antigen
Rat
Flow Cytometry,Functional Assay,Immunohistochemistry (Formalin/Paraffin),Western Blot
eFluor 660
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
0.2mg/mL
HECA-452
Human
RUO
Conjugated
Primary
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer