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(-)-Cotinine, 98%, Thermo Scientific Chemicals

Supplier:  Thermo Scientific Chemicals L11873MD

 View more versions of this product

Catalog No. AAL11873MD



Description

Description

(-)-Cotinine is used to activate a subpopulation of α3/ α6β2 nAChRs in monkey striatum. It binds nicotinic- and muscarinic-type acetylcholine receptors with minimal receptor desensitization and demonstrates antipsychotic drug-like properties in behavioral models, neuroprotective properties in neurodegenerative disease models, and enhances attention in a delayed matching-to-sample task.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Solubility
Not miscible or difficult to mix in water. Soluble in dimethyl sulfoxide (100 mM), ethanol (50 mg/ml, yielding a clear, faint yellow to yellow solution), methanol and chloroform.

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature is 2 - 8°C.
Specifications

Specifications

(-)-Cotinine
34°C to 39°C
>110°C (230°F)
MFCD00077696
83099
cotinine, --cotinine, cotinina, cotininum, cotinine-, s-cotinine, s---cotinine, unii-k5161x06ll, s-1-methyl-5-3-pyridinyl-2-pyrrolidinone, 2-pyrrolidinone, 1-methyl-5-3-pyridinyl-, 5s
UIKROCXWUNQSPJ-VIFPVBQESA-N
CN1C(CCC1=O)C2=CN=CC=C2
176.219
CHEBI:68641
98%
486-56-6
145°C to 147°C (3 mmHg)
C10H12N2O
250 mg
14,2553
Not miscible or difficult to mix in water. Soluble in dimethyl sulfoxide (100 mM),ethanol (50mg/ml,yielding a clear,faint yellow to yellow solution),methanol and chloroform.
−20° (c=1 in Ethanol)
(5S)-1-methyl-5-pyridin-3-ylpyrrolidin-2-one
854019
176.22

Chemical Identifiers

486-56-6
176.219
UIKROCXWUNQSPJ-VIFPVBQESA-N
854019
(5S)-1-methyl-5-pyridin-3-ylpyrrolidin-2-one
C10H12N2O
MFCD00077696
cotinine, --cotinine, cotinina, cotininum, cotinine-, s-cotinine, s---cotinine, unii-k5161x06ll, s-1-methyl-5-3-pyridinyl-2-pyrrolidinone, 2-pyrrolidinone, 1-methyl-5-3-pyridinyl-, 5s
CHEBI:68641
CN1C(CCC1=O)C2=CN=CC=C2
Safety and Handling

Safety and Handling

GHS H Statement
H302-H315-H319-H335
Harmful if swallowed.
Causes skin irritation.
Causes serious eye irritation.
May cause respiratory irritation.

P261-P264b-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P362-P501c

H302-H315-H319-H335

EINECSNumber : 207-634-9

RTECSNumber : GN1925500

TSCA : No

Recommended Storage : Keep cold

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