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Alfa Aesar™ Colchicine, 98%

Microtubule disrupting agent, and induces apoptosis in human lymphoma cells

$74.65 - $456.47

Chemical Identifiers

CAS 64-86-8
Molecular Formula C22H25NO6
Molecular Weight (g/mol) 405.48
MDL Number MFCD00078484
InChI Key IAKHMKGGTNLKSZ-BLYUGYDFSA-N
Synonym colchicine, colchicina, colchicin, condylon, colchicinum, colchisol, colsaloid, colcin, colchineos, 7alphah-colchicine
PubChem CID 45038708
IUPAC Name 2,2,2-trideuterio-N-[(7S)-1,2,3-trimethoxy-9-oxo-10-(trideuteriomethoxy)-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide
SMILES CC(=O)NC1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)OC)OC)OC)OC
View More Specs

Products 3
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
AAJ61072ME View Documents Alfa Aesar™
J61072ME
500mg Each for $74.65
 
AAJ6107203 View Documents Alfa Aesar™
J6107203
1g Each for $130.77
 
AAJ6107206 View Documents Alfa Aesar™
J6107206
5g Each for $456.47
 
Description

Description

Applications
Colchicine is most commonly used to treat gout. It is an inhibitor of microtubule polymerization which blocks chromosome segregation during meiosis. Consequently, it is used to induce polyploidy (tetraploid) in plant cells. It is an antimitotic agent that disrupts microtubules by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.

Solubility
Soluble in ethanol (10 mg/ml), water (45 g/L), chloroform, DMSO and methanol.

Notes
Light sensitive. Incompatible with oxidizing agents.
Specifications

Chemical Identifiers

64-86-8
405.48
IAKHMKGGTNLKSZ-BLYUGYDFSA-N
45038708
CC(=O)NC1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)OC)OC)OC)OC
C22H25NO6
MFCD00078484
colchicine, colchicina, colchicin, condylon, colchicinum, colchisol, colsaloid, colcin, colchineos, 7alphah-colchicine
2,2,2-trideuterio-N-[(7S)-1,2,3-trimethoxy-9-oxo-10-(trideuteriomethoxy)-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide

Specifications

Light Sensitive
~150°C
64-86-8
MFCD00078484
2228813
colchicine, colchicina, colchicin, condylon, colchicinum, colchisol, colsaloid, colcin, colchineos, 7alphah-colchicine
CC(=O)NC1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)OC)OC)OC)OC
405.48
399.44
98%
White to Yellow
500mg
C22H25NO6
UN1544
14,2471
IAKHMKGGTNLKSZ-BLYUGYDFSA-N
2,2,2-trideuterio-N-[(7S)-1,2,3-trimethoxy-9-oxo-10-(trideuteriomethoxy)-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide
45038708
Powder
Colchicine
Safety and Handling

Safety and Handling

GHS H Statement
H300-H340
Fatal if swallowed.
May cause genetic defects.

GHS P Statement
P281-P301+P310-P308+P313-P321-P405-P501a
Use personal protective equipment as required.
IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
IF exposed or concerned: Get medical advice/attention.
Specific treatment (see label).
Store locked up.
Dispose of contents/container in accordance with local/regional/national/international regulations.

Danger

DOTInformation : Transport Hazard Class: 6.1; Packing Group: I; Proper Shipping Name: ALKALOIDS, SOLID, N.O.S.

RTECSNumber : GH0700000

TSCA : TSCA