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Colchicine, 98%, Thermo Scientific Chemicals
Microtubule disrupting agent, and induces apoptosis in human lymphoma cells
Supplier: Thermo Scientific Chemicals J61072ME
Description
Colchicine is most commonly used to treat gout. It is an inhibitor of microtubule polymerization which blocks chromosome segregation during meiosis. Consequently, it is used to induce polyploidy (tetraploid) in plant cells. It is an antimitotic agent that disrupts microtubules by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
ApplicationsColchicine is most commonly used to treat gout. It is an inhibitor of microtubule polymerization which blocks chromosome segregation during meiosis. Consequently, it is used to induce polyploidy (tetraploid) in plant cells. It is an antimitotic agent that disrupts microtubules by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.
Solubility
Soluble in ethanol (10 mg/ml), water (45 g/L), chloroform, DMSO and methanol.
Notes
Light sensitive. Incompatible with oxidizing agents.
Specifications
| Colchicine | |
| ∽150°C (decomposition) | |
| C22H25NO6 | |
| 500 mg | |
| 2228813 | |
| 14,2471 | |
| Soluble in ethanol (10mg/ml),water (45g/L),chloroform,DMSO and methanol. | |
| COC1=C(OC)C(OC)=C2C(CC[C@H](NC(C)=O)C3=CC(=O)C(OC)=CC=C23)=C1 | |
| 399.44 | |
| 399.44 | |
| Powder |
| 64-86-8 | |
| White to Yellow | |
| MFCD00078484,MFCD00078484 | |
| UN1544 | |
| Light sensitive | |
| colchicine, colchicina, colchicin, condylon, colchicinum, colchisol, colsaloid, colcin, colchineos, 7alphah-colchicine | |
| IAKHMKGGTNLKSZ-INIZCTEOSA-N | |
| 2,2,2-trideuterio-N-[(7S)-1,2,3-trimethoxy-9-oxo-10-(trideuteriomethoxy)-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide | |
| 45038708 | |
| 98% |
Chemical Identifiers
| 64-86-8 | |
| 399.44 | |
| IAKHMKGGTNLKSZ-INIZCTEOSA-N | |
| 45038708 | |
| COC1=C(OC)C(OC)=C2C(CC[C@H](NC(C)=O)C3=CC(=O)C(OC)=CC=C23)=C1 |
| C22H25NO6 | |
| MFCD00078484,MFCD00078484 | |
| colchicine, colchicina, colchicin, condylon, colchicinum, colchisol, colsaloid, colcin, colchineos, 7alphah-colchicine | |
| 2,2,2-trideuterio-N-[(7S)-1,2,3-trimethoxy-9-oxo-10-(trideuteriomethoxy)-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide |
Safety and Handling
GHS H Statement
H300-H340
Fatal if swallowed.
May cause genetic defects.
P201-P202-P264b-P270-P281-P301+P310-P308+P313-P330-P501c
H300-H340
DOTInformation : Transport Hazard Class: 6.1; Packing Group: I; Proper Shipping Name: ALKALOIDS, SOLID, N.O.S.
EINECSNumber : 200-598-5
RTECSNumber : GH0700000
TSCA : Yes
Recommended Storage : Ambient temperatures
RUO – Research Use Only