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CMKLR1 Rat anti-Human, Clone: BZ332, eBioscience™

Rat Monoclonal Antibody

$187.05 - $361.05

Specifications

Antigen CMKLR1
Clone BZ332
Host Species Rat
Gene Alias serpentine chemokine-like receptor 1
Species Reactivity Human
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

5013705

 
affymetrix
14-7581-80
25μg Each for $187.05

5013706

 
affymetrix
14-7581-82
100μg Each for $361.05
Description & Specifications

Specifications

Antigen CMKLR1
Clone BZ332
Host Species Rat
Gene Alias serpentine chemokine-like receptor 1
Species Reactivity Human
Applications Flow Cytometry
Regulatory Status RUO
Conjugate Unlabeled
Format Purified
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.5mg/mL

The BZ332 antibody reacts with human chemokine-like receptor 1, CMKLR1. CMKLR1 (also known as ChemR23 or DEZ), is a recently-described serpentine chemoattractant receptor. CMKLR1 has been shown to be expressed by dendritic cells (DC) generated in vitro from monocytes, and to mediate their migration to the proteolytically regulated chemoattractant chemerin. CMKLR1 is expressed by circulating DCs in human blood. Importantly, it is selectively expressed by immature plasmacytoid DCs, but not myeloid DCs, thus enabling discrimination between these two dendritic cell lineages. While CMKLR1 is expressed by circulating pDCs in human blood, mDCs, as well as lymphocytes, monocytes, neutrophils, and eosinophils are negative. Human serum contains a chemoattractant for CMKLR1 which is identical with chemerin; this activity is triggered during blood coagulation, suggesting a mechanism for attraction of pDCs to sites of tissue damage and bleeding. Expression of CMKLR1 and migration to locally activated chemerin may allow the rapid and differential recruitment of pDCs in vivo. Unlike mDCs, circulating pDCs do not respond to inflammatory chemokines.