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Alfa Aesar™ Chloromethyl pivalate, 97%

Chemical Identifiers

Chemical Name or Material Chloromethyl pivalate
CAS 18997-19-8
Molecular Formula C6H11ClO2
Linear Formula (CH3)3CCO2CH2Cl
Formula Weight 150.60g/mol
MDL Number MFCD00000884
UN Number UN2924
Beilstein 1560838
Synonym Chloromethyl trimethylacetate; Pivaloyloxymethyl chloride
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Products
Catalog Number Mfr. No. Quantity Price Quantity    

AAA1196722

 
alfa aesar™
A11967-22
100g CALL N/A N/A
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Description & Specifications

Specifications

Boiling Point 146° to 148°C
Quantity 100g
Flash Point 40°C (104°F)
Chemical Name or Material Chloromethyl pivalate
CAS 18997-19-8
Assay 97%
Molecular Formula C6H11ClO2
Linear Formula (CH3)3CCO2CH2Cl
Formula Weight 150.60g/mol
MDL Number MFCD00000884
UN Number UN2924
Beilstein 1560838
Synonym Chloromethyl trimethylacetate; Pivaloyloxymethyl chloride
Health Hazard 1 Danger
Health Hazard 2 GHS H Statement
H314-H318-H226
Causes severe skin burns and eye damage.
Causes serious eye damage.
Flammable liquid and vapor.
Health Hazard 3 GHS P Statement
P210-P260-P303+P361+P353-P305+P351+P338-P405-P501a
Keep away from heat/sparks/open flames/hot surfaces.
- No smoking.
Do not breathe dust/fume/gas/mist/vapors/spray.
IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do.
Continue rinsing.
Store locked up.
Dispose of contents/container in accordance with local/regional/national/international regulations.
DOT Information Transport Hazard Class: 3; Packing Group: III; Proper Shipping Name: FLAMMABLE LIQUIDS, CORROSIVE, N.O.S.
TSCA TSCA

Applications
Chloromethyl pivalate acts as an intermediate in the synthesis of active pharmaceutical ingredients. It is also involved in the acylation reaction with 9-(2-phosphonylmethoxyethyl)adenine. It serves as a protecting reagent used for the N-protection of amines. It is also employed in the preparation of pivaloyloxy methyl ester of ofloxacin as a prodrug. Further, it is used to prepare sulbactam pivoxil by reaction with sodium salt of sulbactam. In addition to this, it is used as a reagent during the synthesis of an isoindoline-annulated and continuous-flow organic synthesis.

Solubility
Miscible with most organic solvents. Immiscible with water.

Notes
Incompatible with strong oxidizing agents.

Safety and Handling

Danger

GHS P Statement
P210-P260-P303+P361+P353-P305+P351+P338-P405-P501a
Keep away from heat/sparks/open flames/hot surfaces.
- No smoking.
Do not breathe dust/fume/gas/mist/vapors/spray.
IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do.
Continue rinsing.
Store locked up.
Dispose of contents/container in accordance with local/regional/national/international regulations.

GHS H Statement
H314-H318-H226
Causes severe skin burns and eye damage.
Causes serious eye damage.
Flammable liquid and vapor.