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Chloromethyl pivalate, 97%, Thermo Scientific Chemicals
Supplier: Thermo Scientific Chemicals A1196714
Description
Chloromethyl pivalate acts as an intermediate in the synthesis of active pharmaceutical ingredients. It is also involved in the acylation reaction with 9-(2-phosphonylmethoxyethyl)adenine. It serves as a protecting reagent used for the N-protection of amines. It is also employed in the preparation of pivaloyloxy methyl ester of ofloxacin as a prodrug. Further, it is used to prepare sulbactam pivoxil by reaction with sodium salt of sulbactam. In addition to this, it is used as a reagent during the synthesis of an isoindoline-annulated and continuous-flow organic synthesis.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
ApplicationsChloromethyl pivalate acts as an intermediate in the synthesis of active pharmaceutical ingredients. It is also involved in the acylation reaction with 9-(2-phosphonylmethoxyethyl)adenine. It serves as a protecting reagent used for the N-protection of amines. It is also employed in the preparation of pivaloyloxy methyl ester of ofloxacin as a prodrug. Further, it is used to prepare sulbactam pivoxil by reaction with sodium salt of sulbactam. In addition to this, it is used as a reagent during the synthesis of an isoindoline-annulated and continuous-flow organic synthesis.
Solubility
Miscible with most organic solvents. Immiscible with water.
Notes
Incompatible with strong oxidizing agents.
Specifications
| Chloromethyl pivalate | |
| 1.045 | |
| 40°C (104°F) | |
| 1.417 | |
| MFCD00000884 | |
| UN2924 | |
| chloromethyl pivalate, propanoic acid, 2,2-dimethyl-, chloromethyl ester, pivalic acid chloromethyl ester, pivaloyloxymethyl chloride, pivaloylmethyl chloride, chloromethyl trimethylacetate, 2,2-dimethylpropionic acid chloromethyl ester, chioromethyl pivalate, chloromethyl pivaloate, chloro-methyl pivalate | |
| GGRHYQCXXYLUTL-UHFFFAOYSA-N | |
| chloromethyl 2,2-dimethylpropanoate | |
| 87885 | |
| 97% |
| 18997-19-8 | |
| 146°C to 148°C | |
| C6H11ClO2 | |
| (CH3)3CCO2CH2Cl | |
| 25 g | |
| 1560838 | |
| Miscible with most organic solvents. Immiscible with water. | |
| CC(C)(C)C(=O)OCCl | |
| 150.60 | |
| 150.6 |
Chemical Identifiers
| 18997-19-8 | |
| 150.60 | |
| GGRHYQCXXYLUTL-UHFFFAOYSA-N | |
| 87885 | |
| CC(C)(C)C(=O)OCCl |
| C6H11ClO2 | |
| MFCD00000884 | |
| chloromethyl pivalate, propanoic acid, 2,2-dimethyl-, chloromethyl ester, pivalic acid chloromethyl ester, pivaloyloxymethyl chloride, pivaloylmethyl chloride, chloromethyl trimethylacetate, 2,2-dimethylpropionic acid chloromethyl ester, chioromethyl pivalate, chloromethyl pivaloate, chloro-methyl pivalate | |
| chloromethyl 2,2-dimethylpropanoate |
Safety and Handling
GHS H Statement
H314-H318-H226
Causes severe skin burns and eye damage.
Causes serious eye damage.
Flammable liquid and vapor.
P210-P233-P235-P240-P241-P242-P243-P260-P264b-P270-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P310-P330-P331-P363-P370+P378q-P501c
H226-H302-H312-H314-H332-H335
DOTInformation : Transport Hazard Class: 3; Packing Group: III; Proper Shipping Name: FLAMMABLE LIQUIDS, CORROSIVE, N.O.S.
EINECSNumber : 242-735-1
TSCA : Yes
Recommended Storage : Ambient temperatures
RUO – Research Use Only