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Cep55/c10orf3 Mouse anti-Human, Clone: EMRC10-11-55, eBioscience™

Mouse Monoclonal Antibody

$129.05 - $317.55

Specifications

Antigen Cep55/c10orf3
Clone EMRC10-11-55
Host Species Mouse
Gene Alias Centrosomal protein, c10orf3
Species Reactivity Human
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

501122873

 
affymetrix
14980980
25μg Each for $129.05

501122874

 
affymetrix
14980982
100μg Each for $317.55
Description & Specifications

Specifications

Antigen Cep55/c10orf3
Clone EMRC10-11-55
Host Species Mouse
Gene Alias Centrosomal protein, c10orf3
Species Reactivity Human
Applications Immunohistochemistry (Formalin/Paraffin)
Applications Western Blotting
Regulatory Status RUO
Conjugate Unlabeled
Format Purified
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.5mg/mL

The monoclonal antibody EMRC10-11-55 recognizes the human centrosomal protein (Cep55). Cep55 is a 55kDa microtubule-bundling protein that is found throughout the cell but specifically localizes to the mitotic spindle during metaphase and the midbody during anaphase. Cep55 is necessary for the completion of cytokenesis, a process that if disregulated promotes tumorigenesis via a mechanism of aneuploidy and chromosomal instablility. Cep55 is downstream of the transcription factor FOXM1, and has been found to be overexpressed in a head and neck squamous cell carcinoma (HNSCC), hepatocellular carcinoma, breast cancer, colorectal carcinoma (CRC), and in secondary metastatic sites. Expression has been found to correlate with severity of disease and as a cancer biomarker is prognostic of poor outcome in breast cancer. Cep55 is expressed at very modest levels in normal tissue, but is more prominent in testis and thymus.