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CDK7/Cyclin H/MNAT1 Recombinant Human Protein DFS Item

CDK7/Cyclin H/MNAT1 Recombinant Human Protein

Manufacturer:  Life Technologies LSPV3868

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Catalog No. PV3868



The trimeric complex of CDK7, cyclin H and MNAT1, functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This complex is thought to serve as a direct link between the regulation of transcription and the cell cycle.


NP_001790, Q130R I NP_001230 I NP_002422
Pharma and biopharma, protein assays and analysis, target and lead identification and validation
80% by SDS-PAGE
1 Each
CDK7/Cyclin H/MNAT1
CDK7/Cyclin H/MNAT1 was pre-diluted in enzyme dilution buffer and assayed in 12.5mM Tris (pH 7.5), 10mM MgCl2, 1mM EGTA, 0.5mM Na3VO4, 5mM β−glycerophosphate, 2.5mM DTT, 0.01% Triton™ X-100, 200 μM ATP, 333μg/mL CDK7/9tide peptide substrate (YSPTSPSYSPTSPSYSPTSPSKKKK) and trace [32P]-γ-ATP for 10 minutes at 30°C
Kinases and inhibitors
CDK and CHK kinase family
92nmoles of phosphate transferred to CDK7/9tide peptide substrate (YSPTSPSYSPTSPSYSPTSPSKKKK) per minute per mg of total protein at 30°C. Activity determined at a final protein concentration of 3.33μg/mL
His Tag
1022, 1385, 1387, 1390, 4331, 902
CDK7/Cyclin H/MNAT1 Recombinant Human Protein
For research use only. Not for use in diagnostic procedures
Serine/threonine kinase
CDK7/Cyclin H/MNAT1 Recombinant Human Protein
Kinase assay
CDK7/cyclin H/MNAT1 Recombinant Human Protein

For Research Use Only. Not for use in diagnostic procedures.