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CDK5/p25 Recombinant Human Protein DFS Item

CDK5/p25 Recombinant Human Protein

Manufacturer:  Life Technologies LSPV4676

Catalog No. PV4676



Description

Description

CDK5 plays a critical role in neuron development. The disregulation of the CDK5 and the truncated activator p25 is believed to be involved in neurodegenerative diseases such as Alzheimer's, Parkinson's, and Amyotrophic Lateral Sclerosis. This protein is coexpressed and copurified with p25.
Specifications

Specifications

NP_004926.1, NP_003876
Pharma and biopharma, protein assays and analysis, target and lead identification and validation
CDK5/p25 Recombinant Human Protein
10μg
For research use only. Not for use in diagnostic procedures
Serine/threonine kinase
CDK5/p25 Recombinant Human Protein
Kinase assay
Baculovirus
CDK5/p25 Recombinant Human Protein
Human
0.41mg/mL
36.7/51, 87.7kDa
90% by SDS-PAGE
–80°C
1 Each
CDK5/p25, CDK5R
CDK5/p25 was pre-diluted in enzyme dilution buffer and assayed in 20mM Tris (pH 7.5), 5mM MgCl2, 100μM ATP, 800μg/mL RbING peptide substrate (INGSPRTPRRGQNR) and trace [32P]-γ-ATP for 10 minutes at 30°C
Kinase and inhibitors
CDK and CHK
8390nmoles of phosphate transferred to RbING peptide substrate (INGSPRTPRRGQNR) per minute per mg of total protein at 30°C. Activity determined at a final protein concentration of 0.0313μg/mL
GST Tag, His Tag
Documents

For Research Use Only. Not for use in diagnostic procedures.