Thermo Scientific™ Lab Vision™ Cdk2 Ab-4, Mouse Monoclonal Antibody
Ensure accurate, reproducible results in western blotting, immunofluorescence and immunoprecipitation experiments with Thermo Scientific™ Cdk2 Ab-4, Mouse Monoclonal Antibody.
Manufacturer: Thermo Scientific™ Lab Vision™ MS617P1ABX
Ensure accurate, reproducible results in Western Blotting, Immunofluorescence and Immunoprecipitation experiments with Thermo Scientific™ Cdk2 Ab-4, Mouse Monoclonal Antibody.p33cdk2 associates with cyclin A in human cells. Kinase activity associated with cyclin A-cdc2 is found only in G2-phase. Cdk2 also complexes with cyclins E, D1, and D3. Cyclin E-cdk2 kinase is active in the G1- and S-phases of the cell cycle and is important (as does cyclin A-cdk2) for the progression from G1-to S-phase. The levels of cyclin A-cdk2 is maximal at the G1/S transition and both cdk2 and cyclin A are found associated with DNA in the initiation complex during replication. Rb protein acts as substrate for cdk2-cyclin E and/or cdk2-cyclin A in vivo. Cdk2 is activated and specifically localized to the nucleus during late G1-, S-, and G2-phase.
Host Species: Mouse
Clone: 2B6 + 8D4
Isotype: IgG2b (2B6) + IgG2a (8D4)
Species Reactivity: Human, Mouse and Rat. Others not known.
Epitope: Not determined
Immunogen: Human recombinant Cdk2 protein
Molecular Weight: 33 kDa
Positive Control: HeLa cells
Cellular Localization: Cytoplasmic and nuclear
- Western Blotting
- Immunoprecipitation (Denatured only)
USA: RUO; Int'l: RUO
|Human recombinant cdk2 protein|
|2B6 + 8D4|