Invitrogen™ CDK14 (PFTK1)/cyclin Y Recombinant Human Protein
CDK14 (PFTK1)/cyclin Y is a member of the CDC2-related protein kinase family. Recombinant human full-length CDK14 and Cyclin Y (2-end) were co-expressed by baculovirus in Sf9 insect cells using N-terminal GST tags.
Manufacturer: Invitrogen™ LSPV6382
CDK14 (PFTK1)/cyclin Y is expressed primarily in the postnatal and adult nervous system. CDK14 is expressed at high levels in brain, pancreas, kidney, heart, testis, and ovary. CDK14 amino acid residue ser119 is required for its interaction with all four 14-3-3 isoforms, while ser120 may contribute slightly to CDK14 binding. CDK14 acts as a cyclin-dependent kinase that regulates cell cycle progression and cell proliferation. Overexpression of CDK14 predicts resistance to chemotherapy in patients with oesophageal squamous cell carcinoma.
- Validated in LanthaScreen™ Kinase Binding Assay
- Protocols available for simple use and optimized performance
- Multiple pack sizes available for convenient use
|50mM Tris-HCl pH 7.5, 150mM NaCl, 0.25mM DTT, 10mM glutathione, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol|
|aa Full, 2-end|
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|Store at -68 to -85°C. Aliquot at first use to avoid multiple freeze-thaws.|