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Thermo Scientific™ Lab Vision™ CDC6 Ab-1, Mouse Monoclonal Antibody


Ensure accurate, reproducible results in western blotting and immunoprecipitation experiments with Thermo Scientific™ CDC6 Ab-1, Mouse Monoclonal Antibody.

Manufacturer: thermo scientific™ lab vision™  MS867P1ABX

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Catalog No. MS867P1ABX

  • / Each
 

Description & Specifications

Specifications

Antigen CDC6 Ab-1
Applications Immunoprecipitation
Applications Western Blotting
Classification Monoclonal
Clone DCS-180
Concentration 1mg/mL
Conjugate Unlabeled
Cross Reactivity Human
Format Concentrated
Host Species Mouse
Immunogen Recombinant human CDC6 protein
Isotype IgG1
Quantity 100µL
Regulatory Status RUO
Research Discipline Cell Cycle
Type Primary

Ensure accurate, reproducible results in western blotting and immunoprecipitation experiments with Thermo Scientific™ CDC6 Ab-1, Mouse Monoclonal Antibody.

The replication licensing system acts to ensure that no section of the genome is replicated more than once in a single cell cycle. The origin recognition complex (ORC) and CDC6/CDC18 are needed on chromatin before the licensing reaction can take place. During the transition from a growth-arrested to a proliferative state, transcription of mammalian CDC6 is regulated by the cell cycle transcription factor (E2F protein). Immunoblots show that minichromosome maintenance (MCM) proteins are not associated with chromatin. Competence of G1 phase nuclei to replicate in vitro coincides with maximum CDC6 accumulation and MCM protein binding to chromatin in vivo. Antibodies against CDC6 and MCM5 stain abnormal (neoplastically transformed) cells in cervical smears and sections with remarkably high specificity and sensitivity.

Host Species: Mouse

Clone: DCS-180

Isotype: IgG1

Species Reactivity: Human. Others not known

Epitope: Not determined

Immunogen: Recombinant human CDC6 protein

Molecular Weight: 62 kDa

Positive Control: Raji or MDA231cells

Cellular Localization: Nuclear

Recommended for:

  • Western Blotting
  • Immunoprecipitation (Native and denatured)

Note:

USA: RUO; Int'l: RUO