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Thermo Scientific™ Lab Vision™ CDC6 Ab-1, Mouse Monoclonal Antibody

Ensure accurate, reproducible results in western blotting and immunoprecipitation experiments with Thermo Scientific™ CDC6 Ab-1, Mouse Monoclonal Antibody.

Manufacturer:  Thermo Scientific™ Lab Vision™ MS867P1ABX

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Catalog No. MS867P1ABX


 

Specifications

Description

Ensure accurate, reproducible results in western blotting and immunoprecipitation experiments with Thermo Scientific™ CDC6 Ab-1, Mouse Monoclonal Antibody.

The replication licensing system acts to ensure that no section of the genome is replicated more than once in a single cell cycle. The origin recognition complex (ORC) and CDC6/CDC18 are needed on chromatin before the licensing reaction can take place. During the transition from a growth-arrested to a proliferative state, transcription of mammalian CDC6 is regulated by the cell cycle transcription factor (E2F protein). Immunoblots show that minichromosome maintenance (MCM) proteins are not associated with chromatin. Competence of G1 phase nuclei to replicate in vitro coincides with maximum CDC6 accumulation and MCM protein binding to chromatin in vivo. Antibodies against CDC6 and MCM5 stain abnormal (neoplastically transformed) cells in cervical smears and sections with remarkably high specificity and sensitivity.

Host Species: Mouse

Clone: DCS-180

Isotype: IgG1

Species Reactivity: Human. Others not known

Epitope: Not determined

Immunogen: Recombinant human CDC6 protein

Molecular Weight: 62 kDa

Positive Control: Raji or MDA231cells

Cellular Localization: Nuclear

Recommended for:

  • Western Blotting
  • Immunoprecipitation (Native and denatured)

Note:

USA: RUO; Int'l: RUO

Description & Specifications

Specifications

CDC6 Ab-1
Monoclonal
1mg/mL
Concentrated
Recombinant human CDC6 protein
100μL
Cell Cycle
Monoclonal
Immunoprecipitation,Western Blotting
DCS-180
Unlabeled
Murine
IgG1
RUO
Primary
Human