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CD9 Mouse anti-Human, PE, Clone: eBioSN4 (SN4 C3-3A2), eBioscience™

Mouse Monoclonal Antibody

$158.05 - $332.05

Specifications

Antigen CD9
Clone eBioSN4 (SN4 C3-3A2)
Host Species Mouse
Gene Alias MIC3, MRP-1
Species Reactivity Human
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 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

5010203

 
affymetrix
12-0098-41
25 tests Each for $158.05

5010204

 
affymetrix
12009842
100 tests Each for $332.05
Description & Specifications

Specifications

Antigen CD9
Clone eBioSN4 (SN4 C3-3A2)
Host Species Mouse
Gene Alias MIC3, MRP-1
Species Reactivity Human
Applications Flow Cytometry
Regulatory Status RUO
Conjugate PE
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 5μL (0.06μg)/test

The eBioSN4 monoclonal antibody reacts with human CD9. CD9 is a 24kDa member of the tetraspanin family, whose members are characterized by the presence of 4 hydrophobic transmembrane domains. CD9 is expressed in platelets, eosinophils, basophils, pre-B cells, activated T cells and neural cell lines. Furthermore, CD9 expression has been associated with a malignant phenotype, including expression on 90% of non T cell acute lymphoblastic leukemia cells and on 50% of chronic lymphocytic and acute myeloblastic leukemias. In platelets, CD9 is expressed in α-granules and through association with the integrin αIIb/βIII plays a role in platelet aggregation, as demonstrated by the use of anti-human CD9 antibodies. CD9 has also been shown to induce the aggregation of pre-B cell lines, and the adhesion and migration of pre-B cells and Schwann cells. Additionally, it has been demonstrated that CD9 is able to provide a co-stimulatory signal for T cells independently of CD28, in the absence of antigen-presenting cells. Binding of the eBioSN4 monoclonal antibody partially cross-blocks binding of another anti-human CD9 monoclonal antibody, MM2/57.