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CD86 (B7-2) Rat anti-Mouse, PE, Clone: PO3.1, eBioscience™

Rat Monoclonal Antibody

$143.55 - $404.55

Specifications

Antigen CD86 (B7-2)
Clone PO3.1
Host Species Rat
Gene Alias B72, B7.2, B70, Ly-58
Species Reactivity Mouse
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

5010496

 
affymetrix
12086181
50μg Each for $143.55

5010497

 
affymetrix
12086182
100μg Each for $274.05

501122250

 
affymetrix
12086183
200μg Each for $404.55
Description & Specifications

Specifications

Antigen CD86 (B7-2)
Clone PO3.1
Host Species Rat
Gene Alias B72, B7.2, B70, Ly-58
Species Reactivity Mouse
Applications Flow Cytometry
Regulatory Status RUO
Conjugate PE
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.2mg/mL

The PO3.1 monoclonal antibody reacts with mouse CD86, an ∽80kDa surface receptor also known as B7-2. CD86 and CD80 are members of the B7 family of costimulatory molecules. CD86 is expressed at low level on B cells, macrophages, and dendritic cells and is upregulated on B cells through a variety of surface stimuli including the BCR complex, CD40 and some cytokine receptors. CD86 is also expressed by activated mouse T cells and thioglycolate-elicited peritoneal cells. In addition to CD80 (B7-1), CD86 is a counter-receptor for the T cell surface molecules CD28 and CD152 (CTLA-4). The interaction of CD86 with its ligands plays a critical role in T-B crosstalk, T cell costimulation, autoantibody production and Th2-mediated Ig production. The kinetics of upregulation of CD86 upon stimulation supports its major contribution during the primary phase of an immune response.