Please login to your online account to display your discounted pricing

CD86 (B7-2) Rat anti-Mouse, Clone: PO3.1, Functional Grade, eBioscience™

Rat Monoclonal Antibody, Functional Grade

$143.55 - $433.55

Specifications

Antigen CD86 (B7-2)
Clone PO3.1
Host Species Rat
Gene Alias B70, Ly-58
Species Reactivity Mouse
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

5014402

 
affymetrix
16086181
50μg Each for $143.55

5014404

 
affymetrix
16086185
500μg Each for $433.55
Description & Specifications

Specifications

Antigen CD86 (B7-2)
Clone PO3.1
Host Species Rat
Gene Alias B70, Ly-58
Species Reactivity Mouse
Applications Flow Cytometry
Applications Functional Assay
Regulatory Status RUO
Conjugate Unlabeled
Format Purified
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, no sodium azide
Concentration 1mg/mL

The PO3.1 monoclonal antibody reacts with mouse CD86, an ∽80kDa surface receptor also known as B7-2. CD86 and CD80 are members of the B7 family of costimulatory molecules. CD86 is expressed at low level on B cells, macrophages, and dendritic cells and is upregulated on B cells through a variety of surface stimuli including the BCR complex, CD40 and some cytokine receptors. CD86 is also expressed by activated mouse T cells and thioglycolate-elicited peritoneal cells. In addition to CD80 (B7-1), CD86 is a counter-receptor for the T cell surface molecules CD28 and CD152 (CTLA-4). The interaction of CD86 with its ligands plays a critical role in T-B crosstalk, T cell costimulation, autoantibody production and Th2-mediated Ig production. The kinetics of upregulation of CD86 upon stimulation supports its major contribution during the primary phase of an immune response.