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CD86 (B7-2) Mouse anti-Rat, FITC, Clone: 24F, eBioscience™

Mouse Monoclonal Antibody

$129.05 - $245.05

Specifications

Antigen CD86 (B7-2)
Clone 24F
Host Species Mouse
Gene Alias B72
Species Reactivity Rat
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

509684

 
life technologies
LS11086081
50μg Each for $129.05

509685

 
life technologies
LS11086082
100μg Each for $245.05
Description & Specifications

Specifications

Antigen CD86 (B7-2)
Clone 24F
Host Species Mouse
Gene Alias B72
Species Reactivity Rat
Applications Flow Cytometry
Regulatory Status RUO
Conjugate FITC
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.5mg/mL

The 24F monoclonal antibody reacts with rat CD86, an ∽90kDa surface receptor, also known as B7-2. CD86 and CD80 are members of the B7 family of costimulatory molecules. CD86 is expressed by germinal center B cells and at low levels on macrophages, dendritic cells and non-lymphoid cells in the thymus. Its expression is upregulated on B cells through a variety of surface stimuli including LPS. In addition to CD80 (B7-1), CD86 is a counter-receptor for the T cell surface molecules CD28 and CD152 (CTLA-4). The interaction of CD86 with its ligands plays a critical role in T-B crosstalk, T cell costimulation, autoantibody production and Th2-mediated Ig production. The kinetics of upregulation of CD86 upon stimulation supports its major contribution during the primary phase of an immune response.