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CD86 (B7-2) Mouse anti-Human, Biotin, Clone: IT2.2, eBioscience™

Mouse Monoclonal Antibody

$129.05 - $317.55

Specifications

Antigen CD86 (B7-2)
Clone IT2.2
Host Species Mouse
Gene Alias B72, B70
Species Reactivity Human
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

5011656

 
affymetrix
13-0869-80
25μg Each for $129.05

5011657

 
affymetrix
13-0869-82
100μg Each for $317.55
Description & Specifications

Specifications

Antigen CD86 (B7-2)
Clone IT2.2
Host Species Mouse
Gene Alias B72, B70
Species Reactivity Human
Applications Flow Cytometry
Regulatory Status RUO
Conjugate Biotin
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.5mg/mL

The IT2.2 monoclonal antibody reacts with human CD86, an ∽80kDa surface receptor also known as B7-2. CD86 and CD80 are members of the B7 family of costimulatory molecules. CD86 is expressed at low levels on B cells, macrophages, and dendritic cells and is upregulated on B cells through a variety of surface stimuli including the BCR complex, CD40 and some cytokine receptors. In addition to CD80 (B7-1), CD86 is a counter-receptor for the T cell surface molecules CD28 and CD152 (CTLA-4). The interaction of CD86 with its ligands plays a critical role in T-B crosstalk, T cell costimulation, autoantibody production and Th2-mediated Ig production. The kinetics of upregulation of CD86 upon stimulation supports its major contribution during the primary phase of an immune response.