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CD85j (ILT2) Mouse anti-Human, APC, Clone: HP-F1, eBioscience™

Mouse Monoclonal Antibody

$201.55 - $462.55

Specifications

Antigen CD85j (ILT2)
Clone HP-F1
Host Species Mouse
Gene Alias LIR1, LILRB1, MIR7
Species Reactivity Human
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

5015187

 
affymetrix
17512941
25 tests Each for $201.55

5015188

 
affymetrix
17512942
100 tests Each for $462.55
Description & Specifications

Specifications

Antigen CD85j (ILT2)
Clone HP-F1
Host Species Mouse
Gene Alias LIR1, LILRB1, MIR7
Species Reactivity Human
Applications Flow Cytometry
Regulatory Status RUO
Conjugate APC
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 5μL (0.25μg)/test

The monoclonal antibody HP-F1 recognizes CD85j, also known as ILT2, LILRB1, and LIR1. CD85j is a member of the ILT (immunoglobulin-like transcript)/LIR (leukocyte Ig-like receptor)/MIR (monocyte Ig-like receptor) family. CD85j is a single transmembrane glycoprotein with a long cytoplasmic domain containing 4 ITIMs which signal through interactions with SHP-1. Expression is found on myeloid cells (monocytes and dendritic cells) and some lymphoid cells including, subsets of NK, T and B cells. Expression has been correlated with leukemias such as ALL and CLL. Expression on CD8+ cells correlates with effector cell function and plays an important role in viral infections, including HIV, Ebstein Barr and CMV. The ligands for CD85j are MHC Class I molecules such as HLA-G, A, F, B27, E and F.

The monoclonal antibody HP-F1 has been shown to reduce the amount of CD16- dependent cytolytic activity of functional NK cells.