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CD85g (ILT7) Mouse anti-Human, PE, Clone: eBio17G10.2 (17G10.2), eBioscience™

Mouse Monoclonal Antibody

$201.55 - $419.05

Specifications

Antigen CD85g (ILT7)
Clone eBio17G10.2 (17G10.2)
Host Species Mouse
Gene Alias ILT-7, LILRA4
Species Reactivity Human
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

5010809

 
affymetrix
12-5179-41
25 tests Each for $201.55

5010810

 
affymetrix
12-5179-42
100 tests Each for $419.05
Description & Specifications

Specifications

Antigen CD85g (ILT7)
Clone eBio17G10.2 (17G10.2)
Host Species Mouse
Gene Alias ILT-7, LILRA4
Species Reactivity Human
Applications Flow Cytometry
Regulatory Status RUO
Conjugate PE
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 5μL (0.125μg)/test

The eBio17G10.2 monoclonal antibody reacts with human immunoglobulin-like transcript 7 (ILT7), also known as CD85g. ILT7 is part of the leukocyte immunoglobulin-like receptor (LIR) gene family and associates with Fc epsilon R1 gamma to form a functional complex which transduces ITAM-mediated signals that negatively modulates TLR-induced type I IFN production by human plasmacytoid dendritic cells. ILT7 is expressed exclusively on plasmacytoid dendritic cells and is absent in monocyte derived DCs. Treatment with IL-3 or CpG causes a decrease in expression.

Double staining of human PBMCs with eBio17G10.2 and anti-pDC marker BDCA2 yields virtually complete co-staining. Cross linking of ILT7 with eBio17G10.2 antibody causes reduced transcription of IFN alpha1, IFN alpha2, IFN alpha4 and IFN beta.