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CD8 Mouse anti-Human, Clone: OKT8 (OKT-8), Functional Grade, eBioscience™

Mouse Monoclonal Antibody, Functional Grade

$158.05 - $477.05

Specifications

Antigen CD8
Clone OKT8 (OKT-8)
Host Species Mouse
Gene Alias CD8 alpha, leu-2a
Species Reactivity Human
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

5014217

 
affymetrix
16-0086-81
50μg Each for $158.05

5014218

 
affymetrix
16-0086-85
500μg Each for $477.05
Description & Specifications

Specifications

Antigen CD8
Clone OKT8 (OKT-8)
Host Species Mouse
Gene Alias CD8 alpha, leu-2a
Species Reactivity Human
Applications Flow Cytometry
Regulatory Status RUO
Conjugate Unlabeled
Format Purified
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, no sodium azide

The OKT8 monoclonal antibody reacts with the human CD8a molecule, an approximately 32-34kDa cell surface receptor expressed either as a heterodimer with the CD8 β chain (CD8 αβ) or as a homodimer (CD8 αα). A majority of thymocytes and a subpopulation of mature T cells and NK cells express CD8a. CD8 binds to MHC class I and through its association with protein tyrosine kinase p56lck plays a role in T-cell development and activation of mature T cells. Preliminary testing indicates that OKT8 and two other mouse anti-human CD8 antibodies (clone RPA-T8, Cat. No.14-0088 and clone HIT8a, Cat. No.14-0089) do not compete with each other for binding to human peripheral blood leukocytes by flow cytometric analysis, suggesting that they do not bind to similar epitopes or block each other by steric hindrance.