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CD74 Mouse anti-Human, FITC, Clone: 5-329, eBioscience™

Mouse Monoclonal Antibody

$117.48 - $275.88

Specifications

Antigen CD74
Clone 5-329
Host Species Murine
Gene Alias Invariant chain, MHC Class II-associated, Ia-gamma, Receptor for Macrophage Migration Inhibitory Factor
Species Reactivity Human
View More Specs

Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
509664 Life Technologies
LS11074841
25 Tests Each for $117.48
509665 Life Technologies
LS11074842
100 Tests Each for $275.88
Specifications

Description

This 5-329 monoclonal antibody recognizes human CD74, also known as the MHC Class II-associated invariant chain. A 33-43kDa nonpolymorphic type II membrane protein, CD74 is highly expressed on B cells and subsets of activated T cells, Langerhans cells, dendritic cells, and epithelial cells. Monocytes and macrophages also express CD74, but at lower levels. CD74 acts as a chaperone of MHC Class II (HLA-DR) proteins, promoting their translocation from the ER to endocytic compartments during antigen presentation. Activation of NFκB and ERK has been shown following CD74 interaction with CD44 and binding to the proinflammatory cytokine macrophage migration-inhibitory factor (MIF). CD74 also plays a role in the maturation of follicular B-cells and accumulation of marginal zone B-cells. CD74 has also been demonstrated to interact with CXCR2 and CXCR4.
Description & Specifications

Specifications

CD74
Murine
Human
RUO
Conjugated
Primary
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
5-329
Invariant chain, MHC Class II-associated, Ia-gamma, Receptor for Macrophage Migration Inhibitory Factor
Flow Cytometry
FITC
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
5μL (0.125μg)/test