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CD74 Mouse anti-Human, FITC, Clone: 5-329, eBioscience™

Mouse Monoclonal Antibody

$129.05 - $303.05

Specifications

Antigen CD74
Clone 5-329
Host Species Mouse
Gene Alias Invariant chain, MHC Class II-associated, Ia-gamma, Receptor for Macrophage Migration Inhibitory Factor
Species Reactivity Human
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

509664

 
affymetrix
11074841
25 tests Each for $129.05

509665

 
affymetrix
11074842
100 tests Each for $303.05
Description & Specifications

Specifications

Antigen CD74
Clone 5-329
Host Species Mouse
Gene Alias Invariant chain, MHC Class II-associated, Ia-gamma, Receptor for Macrophage Migration Inhibitory Factor
Species Reactivity Human
Applications Flow Cytometry
Regulatory Status RUO
Conjugate FITC
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 5μL (0.125μg)/test

This 5-329 monoclonal antibody recognizes human CD74, also known as the MHC Class II-associated invariant chain. A 33-43kDa nonpolymorphic type II membrane protein, CD74 is highly expressed on B cells and subsets of activated T cells, Langerhans cells, dendritic cells, and epithelial cells. Monocytes and macrophages also express CD74, but at lower levels. CD74 acts as a chaperone of MHC Class II (HLA-DR) proteins, promoting their translocation from the ER to endocytic compartments during antigen presentation. Activation of NFκB and ERK has been shown following CD74 interaction with CD44 and binding to the proinflammatory cytokine macrophage migration-inhibitory factor (MIF). CD74 also plays a role in the maturation of follicular B-cells and accumulation of marginal zone B-cells. CD74 has also been demonstrated to interact with CXCR2 and CXCR4.