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CD74 Mouse anti-Human, Clone: VIC-Y1, eBioscience™

Mouse Monoclonal Antibody

$85.55 - $158.05

Specifications

Antigen CD74
Clone VIC-Y1
Host Species Mouse
Species Reactivity Human
Applications Immunohistochemistry (Formalin/Paraffin)
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

5012702

 
affymetrix
14074780
25μg Each for $85.55

5012703

 
affymetrix
14074782
100μg Each for $158.05
Description & Specifications

Specifications

Antigen CD74
Clone VIC-Y1
Host Species Mouse
Species Reactivity Human
Applications Immunohistochemistry (Formalin/Paraffin)
Regulatory Status RUO
Conjugate Unlabeled
Format Purified
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.5mg/mL

This VIC-Y1 monoclonal antibody recognizes human CD74, also known as the MHC Class II-associated invariant chain. A 33-43kDa nonpolymorphic type II membrane protein, CD74 is highly expressed on B cells and subsets of activated T cells, Langerhans cells, dendritic cells, and epithelial cells. Monocytes and macrophages also express CD74, but at lower levels. CD74 acts as a chaperone of MHC Class II (HLA-DR) proteins, promoting their translocation from the ER to endocytic compartments during antigen presentation. Activation of NFkB and ERK has been shown following CD74 interaction with CD44 and binding to the proinflammatory cytokine macrophage migration-inhibitory factor (MIF). CD74 also plays a role in the maturation of follicular B-cells and accumulation of marginal zone B-cells. CD74 has also been demonstrated to interact with CXCR2 and CXCR4.

The VIC-Y1 monoclonal antibody binds to a cytoplasmic region of human CD74 and thus cannot be used to detect cell surface expression of this molecule.