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CD73 Mouse anti-Human, eFluor® 450, Clone: AD2, eBioscience™

Mouse Monoclonal Antibody

Manufacturer:  Life Technologies LS48073942

Catalog No. 501129276



Description

Description

Description: This AD2 monoclonal antibody reacts with human CD73, a 5′-ectonucleotidase that converts 5′-adenosine monophosphate to adenosine. CD73 is expressed on the surface of endothelial cells, as well as B and T cells, including some CD4+

CD73 (Ecto-5-prime-nucleotidase, 5-prime-ribonucleotide phosphohydrolase) catalyzes the conversion at neutral pH of purine 5-prime mononucleotides to nucleosides, the preferred substrate being AMP. CD73 consists of a dimer of 2 identical 70 kDa subunits bound externally to the plasma membrane by a glycosyl phosphatidyl inositol linkage. CD73 is used as a marker of lymphocyte differentiation. Consequently, a deficiency of CD73 occurs in a variety of immunodeficiency diseases. Other forms of 5-prime nucleotidase exist in the cytoplasm and lysosomes and can be distinguished from CD73 by their substrate affinities, requirement for divalent magnesium ion, activation by ATP, and inhibition by inorganic phosphate. The CD73 gene has been localized to 6q14-q21 by immunofluorescence and a study of a panel of human x mouse hybrids that contained fragments of chromosome 6 as translocations. Defects in the CD73 gene can lead to the calcification of joints and arteries, and intestinal tuberculosis. Two transcript variants encoding different isoforms of CD73 have been found.
Specifications

Specifications

CD73
Monoclonal
5 μL/Test
PBS with 0.1% gelatin, 0.2% BSA and 0.09% sodium azide; pH 7.2
P21589
CD73, E5NT, NT, NT5, NTE, eN, eNT, 5′-NT, 5′-nucleotidase, Purine 5-Prime-Nucleotidase, ecto-5′-nucleotidase
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Human
Flow Cytometry
AD2
eFluor® 450
NT5E
Liquid
NT5E
IgG1, kappa
100 Tests
4° C, store in dark, DO NOT FREEZE!
Primary
4907
Documents

For Research Use Only.