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CD71 (Transferrin Receptor), PE-Cyanine7, clone: OKT9 (OKT-9), eBioscience™

Mouse Monoclonal Antibody

Manufacturer:  Life Technologies LS25071942

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Catalog No. 501129348



Description

Description

Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Serum transferrin receptor (sTfR) is used as a means of detecting erythropoietin (EPO) misuse by athletes and as a diagnostic test for anemias resulting from a number of conditions including rheumatoid arthritis, pregnancy, irritable bowel syndrome and in HIV patients.

Some generalizations regarding fluorophore performance after fixation can be made, but clone specific performance should be determined empirically. Excitation: 488-561 nm; Emission: 775 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser. Filtration: 0.2 μm post-manufacturing filtered. Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Serum transferrin receptor (sTfR) is used as a means of detecting erythropoietin (EPO) misuse by athletes and as a diagnostic test for anemias resulting from a number of conditions including rheumatoid arthritis, pregcy, irritable bowel syndrome and in HIV patients.
Specifications

Specifications

CD71 (Transferrin Receptor)
Monoclonal
5 μL/Test
PBS with 0.1% gelatin, 0.2% BSA and 0.09% sodium azide; pH 7.2
P02786
CD71, T9, TFR, TFR1, TR, TRFR, p90, transferrin receptor protein 1
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Human
Flow Cytometry
OKT9 (OKT-9)
PE-Cyanine7
TFRC
Liquid
TFRC
IgG1, kappa
100 Tests
4° C, store in dark, DO NOT FREEZE!
Primary
7037
Documents

For Research Use Only.