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CD68 Rat anti-Mouse, eFluor 660, Clone: FA-11, eBioscience™

Rat Monoclonal Antibody

$187.05 - $433.55

Specifications

Antigen CD68
Clone FA-11
Host Species Rat
Gene Alias macrosialin, gp110
Species Reactivity Mouse
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

501124281

 
affymetrix
50068180
25μg Each for $187.05

501124282

 
affymetrix
50068182
100μg Each for $433.55
Description & Specifications

Specifications

Antigen CD68
Clone FA-11
Host Species Rat
Gene Alias macrosialin, gp110
Species Reactivity Mouse
Applications Flow Cytometry (Intracellular Staining)
Applications Immunohistochemistry (Frozen)
Regulatory Status RUO
Conjugate eFluor 660
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.2mg/mL

This FA-11 monoclonal antibody reacts with mouse CD68, known also as macrosialin. CD68 is a heavily O- and N- glycosylated type I integral membrane protein belonging to the sialomucin family and is closely related to the Lysosomal/endosomal-Associated Membrane Glycoproteins (LAMP). Although commonly used as a pan-macrophage marker, low levels of expression have also been observed in Langerhans cells and conventional dendritic cells. CD68 is mostly localized in the late endosomes and lysosomes with a smaller fraction circulating to the cell surface. In the steady state, only about 10-15% of CD68 is present at the surface. Cell stimulation increases expression of CD68, its transport to cell surface, and results in glycoform remodeling. CD68 binds oxidized LDL and is involved in the process of phagocytosis.

The FA-11 antibody is not recommended for use in immunohistochemistry of formalin-fixed paraffin embedded tissues.