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CD61 (Integrin beta 3) Mouse anti-Human, Clone: VI-PL2, eBioscience™

Mouse Monoclonal Antibody

$100.05 - $158.05

Specifications

Antigen CD61 (Integrin beta 3)
Clone VI-PL2
Host Species Mouse
Gene Alias ITGB3
Species Reactivity Baboon, Canine, Cynomolgus, Human, Rhesus Ma
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

5012667

 
affymetrix
14-0619-80
25μg Each for $100.05

5012668

 
affymetrix
14-0619-82
100μg Each for $158.05
Description & Specifications

Specifications

Antigen CD61 (Integrin beta 3)
Clone VI-PL2
Host Species Mouse
Gene Alias ITGB3
Species Reactivity Baboon, Canine, Cynomolgus, Human, Rhesus Ma
Applications Flow Cytometry
Applications Functional Assay
Applications Immunohistochemistry (Frozen)
Applications Western Blotting
Regulatory Status RUO
Conjugate Unlabeled
Format Purified
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.5mg/mL

The VI-PL2 monoclonal antibody reacts with human CD61, also known as integrin beta 3 and GPIIIa. CD61 is a 90-110kDa member of the beta integrin family expressed by a wide variety of cells, including leukocytes, platelets, endothelial and smooth muscle cells. CD61 binds non-covalently with the alpha integrins CD41 and CD51, to form the alpha IIb beta3 (CD41/CD61) and alpha v beta3 (CD51/CD61) complexes. These alpha beta heterodimers are capable of mediating a variety of cellular responses including adhesion, trafficking, proliferaton and differentiation. The CD41/CD61 integrin has been shown to be involved in platelet aggregation, and binds to fibrinogen, von Willebrand Factor (vWF) and fibronectin. The CD51/CD61 integrin binds to matrix proteins including vitronectin, fibronectin, vWF and fibrinogen, and has been shown to have a strong role in modulating the migration and survival of angiogenic endothelial cells.

This VI-PL2 antibody has also been shown to crossreact with canine and several non-human primate species, including baboon, rhesus, and cynomologus monkey.