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CD6 Rat anti-Mouse, Clone: IM348, eBioscience™

Rat Monoclonal Antibody

$85.55 - $143.55

Specifications

Antigen CD6
Clone IM348
Host Species Rat
Species Reactivity Mouse
Applications Flow Cytometry,Immunohistochemistry (Frozen),Western Blot
View More Specs

Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
5012381 Life Technologies
LS14006180
25μg Each for $85.55
5012382 Life Technologies
LS14006182
100μg Each for $143.55
Specifications

Description

The monoclonal antibody IM348 recognizes mouse CD6, a transmembrane glycoprotein of the scavenger receptor family. The extracellular domain contains three scavenger receptor cysteine rich (SRCR) domains, a transmembrane region and a cytoplasmic domain of variable length depending on the isoform. CD6 is expressed on most T lymphocytes. Expression between human and mouse is slightly different. In mice B cells in the spleen do not have CD6, while humans express it on a subset of B lymphocytes. The CD6 ligand is CD166, also known as Activated Leukocyte Cell Adhesion Molecule (ALCAM). Through interactions with CD166 or homotypic CD6-CD6, a role exists in adhesion and migration during organogenesis. The intracellular domain of CD6 is constitutively phosphorylated, suggesting a role in T cell activation and signaling. In humans depletion of CD6-expressing cells increases graft versus host tolerance in transplants.
Description & Specifications

Specifications

CD6
Rat
Flow Cytometry,Immunohistochemistry (Frozen),Western Blot
Unlabeled
Store at 2-8°C.
Monoclonal
0.5mg/mL
IM348
Mouse
RUO
Purified
Primary
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer