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CD49e (Integrin alpha 5) Mouse anti-Human, PE, Clone: P1D6, eBioscience™

Mouse Monoclonal Antibody

$172.55 - $361.05

Specifications

Antigen CD49e (Integrin alpha 5)
Clone P1D6
Host Species Mouse
Gene Alias ITGA5, VLA-5, Fibronectin receptor
Species Reactivity Human
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

5010797

 
affymetrix
12490041
25 tests Each for $172.55

501122317

 
affymetrix
12490042
100 tests Each for $361.05
Description & Specifications

Specifications

Antigen CD49e (Integrin alpha 5)
Clone P1D6
Host Species Mouse
Gene Alias ITGA5, VLA-5, Fibronectin receptor
Species Reactivity Human
Applications Flow Cytometry
Regulatory Status RUO
Conjugate PE
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 5μL (0.25μg)/test

This P1D6 monoclonal antibody reacts with human CD49e, which is also known as integrin alpha 5. Integrins constitute a family of cell surface receptors that mediate adhesion between cells or between a cell and the extracellular matrix. These proteins are heterodimers consisting of two distinct subunits, α and β. Integrin alpha 5 is expressed on thymocytes, T cells, monocytes, platelets, as well as early and activated B cells. Integrins are also expressed on non-hematopoietic and cancer cells. Integrin-mediated adhesion is regulated by changes in ligand affinity (or activation), cell shape, and integrin clustering and diffusion. Integrin alpha 5 undergoes post-translational cleavage in its extracellular domain to produce disulfide-linked light and heavy chains that associate with the common beta 1 subunit to form the fibronectin receptor. Studies have demonstrated the involvement of this integrin in cell adhesion, signaling, and apoptosis.

The P1D6 monoclonal antibody has been reported to have blocking activity. Crossblocking studies indicate that P1D6 and eBioSAM-1 recognize a similar epitope.